Ul Huda Noor, Hassan Noor, Ali Hazrat, Kang Yingqian
National Institute for Biotechnology and Genetic Engineering (NIBGE) - College, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, Pakistan.
Guizhou Key Laboratory of Microbiome and Infectious Disease Prevention and Control & Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou & School of basic Medical Sciences & Institution of One health research, Guizhou Medical University, Gui'an New district, China.
Crit Rev Biotechnol. 2025 Jul 20:1-20. doi: 10.1080/07388551.2025.2529588.
Prodigiosin is an alkaloid, cell-associated, red pigment extensively produced as a secondary metabolite by Gram negative bacterium, . The red pigment holds immense recognition for multifunctional tri-pyrrole structure and as a promising candidate for wide array of industrial applications. The biosynthesis and regulation of prodigiosin in is a complex process, manifesting biological information at multiple cellular levels as genomics, transcriptomics and proteomics. The current review delves into molecular biology of highlighting it as a prolific producer of prodigiosin. This review also highlights crucial aspects of regulatory mechanisms for prodigiosin production in , along with recent advancements in strain improvement and heterologous production of pigment in industrially compliant host. In addition, this review integrates current knowledge on molecular biology and regulation of prodigiosin, addressing the approaches employed for high level of prodigiosin production, potential applications, challenges and future perspective for harnessing industrial potential of prodigiosin in future.
灵菌红素是一种与细胞相关的生物碱红色素，由革兰氏阴性菌大量产生，作为次生代谢产物。这种红色素因其多功能三吡咯结构而备受认可，是众多工业应用的有前景候选物。灵菌红素在[具体细菌名称未给出]中的生物合成和调控是一个复杂过程，在基因组学、转录组学和蛋白质组学等多个细胞层面体现生物信息。当前综述深入探讨[具体细菌名称未给出]的分子生物学，强调其作为灵菌红素丰富生产者的特性。本综述还突出了[具体细菌名称未给出]中灵菌红素生产调控机制的关键方面，以及菌株改良和在符合工业要求的宿主中色素异源生产的最新进展。此外，本综述整合了关于灵菌红素分子生物学和调控的现有知识，阐述了用于高水平生产灵菌红素的方法、潜在应用、挑战以及未来挖掘灵菌红素工业潜力的前景。
