与儿科癌症患者自我报告症状筛查依从性相关的因素。

Factors Associated With Self-Report Symptom Screening Adherence in Pediatric Cancer Patients.

作者信息

Dupuis L Lee, Vettese Emily, Aftandilian Catherine, Agarwal Vibhuti, Baggott Christina, Bradfield Scott M, Crellin-Parsons Nicole, Freyer David R, Kelly Kara M, King Allison A, Kyono Wade, Nagasubramanian Ramamoorthy, Orgel Etan, Roth Michael E, Sherani Farha, Yu Lolie, Grimes Allison C, Beauchemin Melissa P, Klesges Lisa M, Tomlinson George A, Sung Lillian

机构信息

Program in Child Health Evaluative Sciences, the Hospital for Sick Children, Toronto, Ontario, Canada.

Department of Pharmacy, The Hospital for Sick Children and Leslie dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

出版信息

Cancer Med. 2025 Jul;14(14):e71053. doi: 10.1002/cam4.71053.

DOI:10.1002/cam4.71053

PMID:40686265

Abstract

INTRODUCTION

Objective was to describe the association between baseline characteristics and the number of Symptom Screening in Pediatrics Tool (SSPedi) assessments completed over an 8-week period.

METHODS

This was a sub-analysis of a cluster randomized controlled trial among 10 sites that were randomized to the intervention group. Participants were English- or Spanish-speaking pediatric patients 8-18 years of age newly diagnosed with cancer. Participants were prompted to complete SSPedi three times weekly for 8 weeks. The outcome was the number of SSPedi assessments completed during the 8-week period. Factors associated with the number of assessments were determined using mixed effects Poisson regression.

RESULTS

At the 10 intervention sites, 216 patients were included in the analysis. Among these participants, 129 (59.7%) were male, 112 (51.9%) were white, and 83 (38.4%) were Hispanic. The number of SSPedi assessments was significantly higher for participants 11-14 years (rate ratio (RR) 1.13, 95% confidence interval (CI) 1.02-1.25) and 15-18 years (RR 1.15, 95% CI 1.04-1.27) compared to 8-10 years. Participants completed more SSPedi assessments if they were Asian compared to white (RR 1.27, 95% CI 1.10-1.46), non-Hispanic compared to Hispanic (RR 1.15, 95% CI 1.04-1.28) and from families with a household income ≥$60,000 (RR 1.12, 95% CI 1.03-1.21). Participants completed fewer SSPedi assessments if they had solid tumors compared to leukemia (RR 0.91, 95% CI 0.84-0.99).

CONCLUSION

Adherence to three-times weekly SSPedi varied by age, race, ethnicity, cancer diagnosis, and family income. This information may facilitate interventions to support routine symptom screening in clinical practice.

TRIAL REGISTRATION

NCT04614662.

摘要

引言

目的是描述基线特征与8周内完成的儿科症状筛查工具（SSPedi）评估次数之间的关联。

方法

这是一项对10个随机分配到干预组的地点进行的整群随机对照试验的子分析。参与者为新诊断为癌症的8至18岁说英语或西班牙语的儿科患者。参与者被要求每周完成三次SSPedi评估，持续8周。结果是8周内完成的SSPedi评估次数。使用混合效应泊松回归确定与评估次数相关的因素。

结果

在10个干预地点，216名患者纳入分析。在这些参与者中，129名（59.7%）为男性，112名（51.9%）为白人，83名（38.4%）为西班牙裔。与8至10岁的参与者相比，11至14岁（率比（RR）1.13，95%置信区间（CI）1.02至1.25）和15至18岁（RR 1.15，95%CI 1.04至1.27）的参与者完成的SSPedi评估次数显著更多。与白人相比，亚洲参与者完成的SSPedi评估更多（RR 1.27，95%CI 1.10至1.46）；与西班牙裔相比，非西班牙裔参与者完成的更多（RR 1.15，95%CI 1.04至1.28）；家庭收入≥60,000美元的参与者完成的更多（RR 1.12，95%CI 1.03至1.21）；与白血病患者相比，实体瘤患者完成的SSPedi评估更少（RR 0.91，95%CI 0.84至0.99）。