Dupuis L Lee, Vettese Emily, Aftandilian Catherine, Agarwal Vibhuti, Baggott Christina, Bradfield Scott M, Crellin-Parsons Nicole, Freyer David R, Kelly Kara M, King Allison A, Kyono Wade, Nagasubramanian Ramamoorthy, Orgel Etan, Roth Michael E, Sherani Farha, Yu Lolie, Grimes Allison C, Beauchemin Melissa P, Klesges Lisa M, Tomlinson George A, Sung Lillian
Program in Child Health Evaluative Sciences, the Hospital for Sick Children, Toronto, Ontario, Canada.
Department of Pharmacy, The Hospital for Sick Children and Leslie dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Cancer Med. 2025 Jul;14(14):e71053. doi: 10.1002/cam4.71053.
Objective was to describe the association between baseline characteristics and the number of Symptom Screening in Pediatrics Tool (SSPedi) assessments completed over an 8-week period.
This was a sub-analysis of a cluster randomized controlled trial among 10 sites that were randomized to the intervention group. Participants were English- or Spanish-speaking pediatric patients 8-18 years of age newly diagnosed with cancer. Participants were prompted to complete SSPedi three times weekly for 8 weeks. The outcome was the number of SSPedi assessments completed during the 8-week period. Factors associated with the number of assessments were determined using mixed effects Poisson regression.
At the 10 intervention sites, 216 patients were included in the analysis. Among these participants, 129 (59.7%) were male, 112 (51.9%) were white, and 83 (38.4%) were Hispanic. The number of SSPedi assessments was significantly higher for participants 11-14 years (rate ratio (RR) 1.13, 95% confidence interval (CI) 1.02-1.25) and 15-18 years (RR 1.15, 95% CI 1.04-1.27) compared to 8-10 years. Participants completed more SSPedi assessments if they were Asian compared to white (RR 1.27, 95% CI 1.10-1.46), non-Hispanic compared to Hispanic (RR 1.15, 95% CI 1.04-1.28) and from families with a household income ≥$60,000 (RR 1.12, 95% CI 1.03-1.21). Participants completed fewer SSPedi assessments if they had solid tumors compared to leukemia (RR 0.91, 95% CI 0.84-0.99).
Adherence to three-times weekly SSPedi varied by age, race, ethnicity, cancer diagnosis, and family income. This information may facilitate interventions to support routine symptom screening in clinical practice.
NCT04614662.
目的是描述基线特征与8周内完成的儿科症状筛查工具（SSPedi）评估次数之间的关联。
这是一项对10个随机分配到干预组的地点进行的整群随机对照试验的子分析。参与者为新诊断为癌症的8至18岁说英语或西班牙语的儿科患者。参与者被要求每周完成三次SSPedi评估，持续8周。结果是8周内完成的SSPedi评估次数。使用混合效应泊松回归确定与评估次数相关的因素。
在10个干预地点，216名患者纳入分析。在这些参与者中，129名（59.7%）为男性，112名（51.9%）为白人，83名（38.4%）为西班牙裔。与8至10岁的参与者相比，11至14岁（率比（RR）1.13，95%置信区间（CI）1.02至1.25）和15至18岁（RR 1.15，95%CI 1.04至1.27）的参与者完成的SSPedi评估次数显著更多。与白人相比，亚洲参与者完成的SSPedi评估更多（RR 1.27，95%CI 1.10至1.46）；与西班牙裔相比，非西班牙裔参与者完成的更多（RR 1.15，95%CI 1.04至1.28）；家庭收入≥60,000美元的参与者完成的更多（RR 1.12，95%CI 1.03至1.21）；与白血病患者相比，实体瘤患者完成的SSPedi评估更少（RR 0.91，95%CI 0.84至0.99）。
每周三次的SSPedi评估依从性因年龄、种族、民族、癌症诊断和家庭收入而异。这些信息可能有助于在临床实践中支持常规症状筛查的干预措施。
NCT04614662。
