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以研究者为中心的转化模型的内部验证:一项混合方法研究。

Internal validation of researcher-centered translational model: A mixed-method study.

作者信息

Supriya S, Patil Shantanu, Mappillairaju Bagavandas

机构信息

Department of Translational Medicine and Research, SRM Institute of Science and Technology, Chennai, Tamil Nadu, India.

Centre for Statistics, SRM Institute of Science and Technology, Chennai, Tamil Nadu, India.

出版信息

Indian J Pharmacol. 2025 Jul 1;57(4):269-272. doi: 10.4103/ijp.ijp_353_24. Epub 2025 Jul 21.

DOI:10.4103/ijp.ijp_353_24
PMID:40686360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12370222/
Abstract

The study aimed to examine the impact of the researcher-centered Basic Fit Translational Model and Delivery Design framework on outcomes such as visualization, progression, and self-reflection. We collected data through questionnaires, with thirty researchers participating in individual training sessions. The Wilcoxon signed-rank test's statistically significant results (3.0-7.0) demonstrated the ease of model adaptability and the need for researcher-centered model building. The basic fit model helps researchers identify their research type, visualize shortcomings, and collaborate in an extended network, leading to successful completion. The delivery design framework helps parallel-process multiple workflows, reducing translational lag time for patients and the pharma industry.

摘要

该研究旨在考察以研究者为中心的基本适配转化模型和交付设计框架对可视化、进展和自我反思等结果的影响。我们通过问卷调查收集数据,有30名研究人员参加了个人培训课程。威尔科克森符号秩检验的统计学显著结果(3.0 - 7.0)表明了模型适应性的简易性以及构建以研究者为中心的模型的必要性。基本适配模型有助于研究人员确定其研究类型,可视化缺点,并在扩展网络中进行协作,从而成功完成研究。交付设计框架有助于并行处理多个工作流程,减少患者和制药行业的转化滞后时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee8d/12370222/8165cae76dbb/IJPharm-57-269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee8d/12370222/8165cae76dbb/IJPharm-57-269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee8d/12370222/8165cae76dbb/IJPharm-57-269-g001.jpg

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本文引用的文献

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Asia-Inclusive Clinical Research and Development Enabled by Translational Science and Quantitative Clinical Pharmacology: Toward a Culture That Challenges the Status Quo.亚洲包容性临床研究与发展,通过转化科学和定量临床药理学实现:挑战现状的文化。
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Oncologist. 2012;17(12):e48-57. doi: 10.1634/theoncologist.2012-0216.
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