Zhu Zhijing, Ren Guiping, Xiong Shiyi, Ma Yaqi, Yang Yiqian, Wu Aiguo, Peng Hao, Yang Fang
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Laboratory of Advanced Theranostic Materials and Technology, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
J Mater Chem B. 2025 Aug 13;13(32):9679-9697. doi: 10.1039/d5tb01031d.
Rare earth elements, with their distinctive electronic configurations and abundant physicochemical properties, are endowed with remarkable magnetic, optical, and catalytic properties. These characteristics, in turn, play a crucial role in advancing biomedical research and applications. The two-dimensional (2D) spatial structure has a profound impact on the magnetic, optical, and electronic properties of materials. Consequently, 2D materials have attracted extensive research interest in recent years. Rare earth-based two-dimensional materials (RE-2DMs), emerging from the effective integration of rare earth elements and 2D structure, offer boundless possibilities for biomedical research. In this review, we summarize concisely the relevant preparation methods of RE-2DMs. We also explore how the 2D structure modulates the optical, magnetic, and catalytic properties of rare-earth-related materials. Moreover, we review the research and applications in biomedical imaging, therapy, and sensing and monitoring, which capitalize on the unique property characteristics of RE-2DMs. Finally, we look ahead to the challenges and opportunities for the development of these materials in the biomedical field. We anticipate that this review will effectively deepen the understanding of RE-2DMs in the context of biomedicine, thereby providing valuable support for the research and design of such materials in the biomedical domain.
稀土元素具有独特的电子构型和丰富的物理化学性质，因而具备卓越的磁性、光学和催化性能。这些特性反过来又在推动生物医学研究及应用方面发挥着关键作用。二维（2D）空间结构对材料的磁性、光学和电子性能有着深远影响。因此，二维材料近年来引起了广泛的研究兴趣。基于稀土的二维材料（RE-2DMs）通过稀土元素与二维结构的有效整合而产生，为生物医学研究提供了无限可能。在本综述中，我们简要总结了RE-2DMs的相关制备方法。我们还探讨了二维结构如何调节稀土相关材料的光学、磁性和催化性能。此外，我们综述了利用RE-2DMs独特性能特点在生物医学成像、治疗以及传感与监测方面的研究和应用。最后，我们展望了这些材料在生物医学领域发展所面临的挑战与机遇。我们预计本综述将有效地加深在生物医学背景下对RE-2DMs的理解，从而为生物医学领域此类材料的研究和设计提供有价值的支持。
