Mladenovic Violeta, Zaric Radica Zivkovic, Sretenovic Snezana, Bubanja Dragana, Ivosevic Zeljko, Igrutinovic Nebojsa, Nesic Jelena, Djurdjevic Predrag
Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
University Clinical Center Kragujevac, Department of Internal Medicine, Kragujevac, Serbia.
Endocrinol Diabetes Metab Case Rep. 2025 Jul 21;2025(3). doi: 10.1530/EDM-24-0119. Print 2025 Jul 1.
Pancytopenia associated with hypopituitarism has been reported in the literature as a rare occurrence limited to isolated case reports, predominantly associated with Sheehan syndrome. We present the case of a 31-year-old woman who showed hematological features of pancytopenia and normal cellularity of bone marrow. Hematological investigation disclosed no other cause for pancytopenia. Her physical findings (generalized weakness, slow speech and no pubic or axillary hair) and history of a previous massive postpartum hemorrhage suggested Sheehan's syndrome, and the pituitary hormonal studies revealed panhypopituitarism. Her blood cell accounts were completely recovered after 5 months of glucocorticoid and thyroxine replacement therapy. We hereby report our experience of a cure of pancytopenia and the normal marrow originating from hypopituitarism after corticosteroid and thyroid hormone replacement therapy.
Sheehan's syndrome correlates with postpartum hemorrhage and causes pancytopenia. It could be successfully treated with glucocorticoid. It could be successfully treated with thyroxine replacement therapy.
全血细胞减少症与垂体功能减退相关，在文献中报道为罕见情况，仅限于个别病例报告，主要与席汉综合征有关。我们报告了一名31岁女性的病例，该患者表现出全血细胞减少的血液学特征且骨髓细胞计数正常。血液学检查未发现全血细胞减少的其他原因。她的体格检查结果（全身无力、语速缓慢且无阴毛或腋毛）以及既往大量产后出血史提示席汉综合征，垂体激素检查显示全垂体功能减退。经过5个月的糖皮质激素和甲状腺素替代治疗后，她的血细胞计数完全恢复。我们在此报告糖皮质激素和甲状腺激素替代治疗后治愈垂体功能减退所致全血细胞减少症及正常骨髓的经验。
席汉综合征与产后出血相关并导致全血细胞减少症。它可用糖皮质激素成功治疗。它可用甲状腺素替代治疗成功治疗。
