Fatma Mnif, Mouna Elleuch, Nabila Rekik, Mouna Mnif, Nadia Charfi, Mohamed Abid
Endocrinology Department, Hedi Chaker Hospital, (3029) Sfax, Tunisia.
J Med Case Rep. 2011 Oct 3;5:490. doi: 10.1186/1752-1947-5-490.
Sheehan's syndrome is defined by varying degrees of anterior pituitary deficiency due to postpartum ischemic necrosis of the pituitary gland after massive bleeding. It is a rare disorder in western countries and even in Tunisia. Hematologic abnormalities such as normochromic anemia have been reported in these patients. However, pancytopenia is rarely observed.
We describe the case of a 48-year-old Tunisian woman with features of hypopituitarism. Laboratory tests showed pancytopenia that was completely reversed after adequate hormone replacement.
Clinicians should consider the possibility of hypopituitarism as a cause of pancytopenia. This is an original case report that is of interest to hematologists, who should be aware of Sheehan's syndrome as a treatable etiology of pancytopenia for women.
席汉综合征是指产后垂体大量出血后发生缺血性坏死，导致不同程度的垂体前叶功能减退。在西方国家甚至突尼斯，这都是一种罕见的疾病。这些患者曾有正色素性贫血等血液学异常情况报道。然而，全血细胞减少很少见。
我们描述了一名48岁突尼斯女性垂体功能减退的病例。实验室检查显示全血细胞减少，在进行充分的激素替代治疗后完全逆转。
临床医生应考虑垂体功能减退作为全血细胞减少病因的可能性。这是一份原创病例报告，血液科医生应予以关注，他们应意识到席汉综合征是女性全血细胞减少的一种可治疗病因。
