Talimkhani Mohammad Mahdi, Talimkhani Ailin, Dinarvand Vida, Mohamadi Somayeh, Baharlouei Hamzeh
School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Physiotherapy, School of Rehabilitation Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.
Clin Neurophysiol Pract. 2025 Jul 1;10:236-245. doi: 10.1016/j.cnp.2025.06.005. eCollection 2025.
This study investigates the potential effects of combining motor skill learning transfer from the unaffected to the affected hand with multiple sessions of dual-transcranial direct current stimulation (tDCS) over the primary motor cortex to enhance motor skills in stroke patients.
Eleven stroke patients participated in a randomized, sham-controlled, double-blind crossover study. Over two periods separated by a 3-week washout, participants underwent either sham or dual-tDCS concurrently with serial response time tasks (SRTT). Each intervention included 20 min of stimulation during SRTT for three consecutive days. The skill index, the primary variable, was assessed pre-intervention, immediately post-intervention, and 24 h later.
Both groups showed significant improvement in motor skill learning across the three intervention days (P < 0.001). The dual-tDCS group demonstrated significantly greater skill improvement in the affected hand compared to the sham group (P < 0.01), while no significant differences were found for the unaffected hand (P = 0.98).
Multi-session dual-tDCS combined with motor learning tasks significantly enhances motor skill transfer to the affected hand in stroke patients, with greater and more durable effects compared to sham stimulation.
This approach may improve bilateral motor skill transfer and hand fatigue management in stroke rehabilitation.
本研究调查了将运动技能从健侧手转移到患侧手与在初级运动皮层进行多次双相经颅直流电刺激（tDCS）相结合对增强中风患者运动技能的潜在影响。
11名中风患者参与了一项随机、假刺激对照、双盲交叉研究。在两个相隔3周洗脱期的阶段中，参与者在进行序列反应时任务（SRTT）的同时接受假刺激或双相tDCS。每次干预包括在SRTT期间连续3天进行20分钟的刺激。主要变量技能指数在干预前、干预后立即以及24小时后进行评估。
两组在三天的干预过程中运动技能学习均有显著改善（P < 0.001）。与假刺激组相比，双相tDCS组患侧手的技能改善更为显著（P < 0.01），而健侧手未发现显著差异（P = 0.98）。
多阶段双相tDCS与运动学习任务相结合可显著增强中风患者患侧手的运动技能转移，与假刺激相比效果更显著且更持久。
这种方法可能改善中风康复中的双侧运动技能转移和手部疲劳管理。
