Zhao Yuanqin, Liu Lihui, Fan Wei, Qi Man, Liao Bin
Department of Cardiovascular Surgery, The Affiliated Hospital, Southwest Medical University, Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Key Laboratory of Cardiovascular Remodeling and Dysfunction, Luzhou, China.
Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
Front Public Health. 2025 Jul 4;13:1598092. doi: 10.3389/fpubh.2025.1598092. eCollection 2025.
BACKGROUND: Ischemic heart disease (IHD) is one of the leading causes of mortality and disability among the older adults. Studies have shown that air pollution (AP) exacerbates the risk of cardiovascular diseases, particularly IHD, posing significant health threats to older adults and increasing disease burden. Recently, with the rapid advancement of industrial technology, environmental pollution has become increasingly prominent. Therefore, it is of utmost significance to investigate the impact of AP on IHD burden, especially on vulnerable populations such as older individuals. METHODOLOGY: Global Burden of Disease (GBD) Study 2021 data was used to analyze and quantify contemporary global burden of IHD in individuals aged 60 and above due to AP and for trends for the time period between 1990 and 2021 using disease burden indicators such as deaths, DALYs, YLDs, YLLs and corresponding age-standardized rates (ASRs). Specifically, we are in patterns of disease burden of IHD in various subgroups stratified by age, sex, Sociodemographic Index (SDI), and GBD regions and countries. SDI-based analyses were conducted to explore the association between socioeconomic development and IHD burden attributable to AP. In addition, we employed the Bayesian Age-Period-Cohort (BAPC) model to provide future estimates of IHD burden attributable to AP for persons aged ≥60. This study provides a comprehensive overview of disease burden patterns of AP-related IHD from multiple perspectives. RESULTS: Between 1990 and 2021, global IHD burden attributable to AP in individuals aged 60 and above rose in terms of deaths, DALYs, YLDs and YLL, while there was a decline in ASRs. Overall, the disease burden in the older adult population remains high, with older age groups experiencing the greatest burden and the most significant decrease in ASRs. Men consistently faced a higher burden than women. Except for high-SDI regions, the burden increased across all other SDI regions, while ASRs declined across all SDI categories. Regions such as East Asia and South Asia significantly contributed to the global burden, with marked regional differences in ASRs. High-income regions saw a more pronounced decrease in ASRs, whereas low-SDI regions, such as East Asia and South Asia, exhibited slower reductions. China and India together account for over half of the global burden. ASR of IHD attributable to AP generally decreased as SDI increased. Projections for 2036 suggest that the disease burden will continue to rise, while ASRs will gradually decline, with men continuing to bear a higher burden than women. CONCLUSION: Although the ASRs of IHD due to AP in individuals aged 60 and older have generally decreased, the absolute number of cases continues to rise. The burden of IHD varies significantly across different genders, age groups, GBD regions, SDI regions, and countries, with older age groups and males exhibiting higher ASRs. In GBD regions such as East Asia and South Asia, as well as in low-SDI regions and developing countries, inadequate healthcare infrastructure and limited AP control exacerbate the impact of AP, resulting in a disproportionately heavy burden. As the global older adult population continues to grow, the health risks associated with AP-induced IHD are expected to worsen, posing an increasing public health challenge. Public health policies should reduce exposure to AP in men and address lifestyle-related factors in this group. In disease-burdened areas, health care systems need to be improved, air quality control policies need to be strengthened, and more efficient health management practices for older individuals need to be adopted. Public health awareness and informing individuals about risks of AP are also necessary for avoiding future disease burdens. Projections for 2036 are for a significant increase in IHD cases and global public health policies should be directed towards reducing AP and developing efficient health care infrastructure to address future challenges.
背景:缺血性心脏病(IHD)是老年人死亡和残疾的主要原因之一。研究表明,空气污染(AP)会加剧心血管疾病的风险,尤其是缺血性心脏病,对老年人构成重大健康威胁,并增加疾病负担。近年来,随着工业技术的快速发展,环境污染日益突出。因此,研究空气污染对缺血性心脏病负担的影响,特别是对老年人等弱势群体的影响,具有至关重要的意义。 方法:利用《2021年全球疾病负担(GBD)研究》数据,使用死亡、伤残调整生命年(DALYs)、伤残损失生命年(YLDs)、生命损失生命年(YLLs)等疾病负担指标以及相应的年龄标准化率(ASRs),分析和量化1990年至2021年期间60岁及以上人群因空气污染导致的当代全球缺血性心脏病负担及其趋势变化。具体而言,我们研究了按年龄、性别、社会人口指数(SDI)和GBD地区及国家分层的各亚组中缺血性心脏病的疾病负担模式,并基于SDI进行分析,以探讨社会经济发展与空气污染所致缺血性心脏病负担之间的关联。此外,我们采用贝叶斯年龄-时期-队列(BAPC)模型,对60岁及以上人群因空气污染导致的缺血性心脏病负担进行未来预测。本研究从多个角度全面概述了与空气污染相关的缺血性心脏病的疾病负担模式。 结果:1990年至2021年期间,60岁及以上人群中因空气污染导致的全球缺血性心脏病负担在死亡、DALYs、YLDs和YLL方面有所上升,而年龄标准化率则有所下降,但总体上老年人群的疾病负担仍然很高;年龄较大组的负担最重且年龄标准化率下降最为显著;男性一直比女性面临更高的负担。除高SDI地区外,所有其他SDI地区的负担均有所增加,而所有SDI类别中的年龄标准化率均有所下降。东亚和南亚等地区对全球负担贡献显著,年龄标准化率存在明显的地区差异。高收入地区年龄标准化率下降更为明显,而东亚和南亚等低SDI地区的下降速度较慢。中国和印度合计占全球负担的一半以上。因空气污染导致的缺血性心脏病年龄标准化率通常随SDI的增加而降低。2036年的预测表明,疾病负担将继续上升,而年龄标准化率将逐渐下降,男性继续承担比女性更高的负担。 结论:尽管全球60岁及以上人群中因空气污染导致的缺血性心脏病年龄标准化率总体呈下降趋势,但病例绝对数仍在上升。缺血性心脏病负担在不同性别、年龄组、GBD地区、SDI地区和国家之间存在显著差异,年龄较大组和男性的年龄标准化率较高。在东亚和南亚等GBD地区以及低SDI地区和发展中国家,医疗基础设施不足和空气污染控制有限加剧了空气污染的影响,导致负担过重。随着全球老年人口持续增长,空气污染所致缺血性心脏病的健康风险预计将恶化,带来日益严峻的公共卫生挑战。公共卫生政策应减少男性接触空气污染的机会,并解决该群体中与生活方式相关的因素。在疾病负担较重的地区,需要改善医疗系统,加强空气质量控制政策,并采用更有效的老年人健康管理措施。提高公众对空气污染危害的认识并告知个人相关风险,对于避免未来疾病负担也十分必要。2036年的预测显示缺血性心脏病病例将大幅增加,全球公共卫生政策应致力于减少空气污染,并发展高效的医疗基础设施,以应对未来挑战。
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