Zeng Tian, Liu Yitong, Tang Xing, Fu Runshu, Gao Qing, Zhou Wenchao, Fang Jiawen, Zhang Juan, Zou Juan, Li Yukun
Department of Assisted Reproductive Centre, The affiliated Zhuzhou Hospital Xiangya Medical College, Central South University, Zhuzhou, Hunan, China.
Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, Hunan, China.
Front Endocrinol (Lausanne). 2025 Jul 4;16:1579477. doi: 10.3389/fendo.2025.1579477. eCollection 2025.
Branched-chain amino acids (BCAAs), including valine, leucine and isoleucine, are essential nutrient signals that influence mammalian animal metabolism. Many enzymes are involved in the metabolism of BCAAs, such as branched-chain amino acid transaminases (BCATs), branched-chain α-keto acid dehydrogenase (BCKDH), and BCKDH kinase (BCKDK). The aberrant expression of enzymes involved in BCAA metabolism and an imbalance in BCAA amino acid intake can lead to disordered metabolism. Aberrant BCAA metabolism can lead to several diseases, such as human ovarian disease, including ovarian cancer (OC), polycystic ovary syndrome (PCOS), and premature ovarian failure (POF), which are common gynaecological diseases. The overexpression of BCATs is found in OC, which promotes BCAA catalysis to provide a large amount of energy for tumorigenesis. However, BCKDK is overexpressed in epithelial ovarian cancer (EOC), which promotes proliferation and migration via MEK-ERK. In addition, several studies have reported that high levels of BCAAs are increased in the plasma of PCOS and POF patients. This review focuses on the role of BCAA metabolism and potential management methods for OC, PCOS and POF.
支链氨基酸（BCAAs），包括缬氨酸、亮氨酸和异亮氨酸，是影响哺乳动物新陈代谢的必需营养信号。许多酶参与支链氨基酸的代谢，如支链氨基酸转氨酶（BCATs）、支链α-酮酸脱氢酶（BCKDH）和BCKDH激酶（BCKDK）。参与支链氨基酸代谢的酶的异常表达以及支链氨基酸摄入量的失衡会导致代谢紊乱。支链氨基酸代谢异常会导致多种疾病，如人类卵巢疾病，包括卵巢癌（OC）、多囊卵巢综合征（PCOS）和卵巢早衰（POF），这些都是常见的妇科疾病。在卵巢癌中发现BCATs过表达，它促进支链氨基酸催化，为肿瘤发生提供大量能量。然而，BCKDK在上皮性卵巢癌（EOC）中过表达，它通过MEK-ERK促进增殖和迁移。此外，几项研究报告称，多囊卵巢综合征和卵巢早衰患者血浆中的支链氨基酸水平升高。本综述重点关注支链氨基酸代谢在卵巢癌、多囊卵巢综合征和卵巢早衰中的作用以及潜在的管理方法。
