Pan Kai, Xu Jie, Li Feng, Aris Ahmad Zaharin, Yu Huawen, Xu Yuzhu, He Jie, Wang Chengxing, Yu Jie
School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Department of Environment, Faculty of Forestry and Environment, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
iScience. 2025 Jun 14;28(7):112907. doi: 10.1016/j.isci.2025.112907. eCollection 2025 Jul 18.
Metabolic syndrome (MetS) is considered to be an important factor leading to an increased risk of chronic non-communicable diseases. Studies have found that exposure to environmental endocrine disruptors (EEDs) is associated with MetS, but the relationship between the two is unclear. In order to clarify the relationship between the two, a systematic review and meta-analysis were conducted to investigate their association. We searched Web of Science databases, Embase, and PubMed. We then utilized I statistics to assess the literature heterogeneity and pooled the data using both fixed-effects model (I < 50%) and the random effects model (I > 50%) in accordance with the PRISMA guidelines. The results showed that exposure to perfluoroalkyl substances (PFASs) was associated to specific components of MetS, such as PFNA and "high waist circumference" (OR = 1.23, 95% CI: 1.10-1.38), and PFOA and "elevated blood pressure" (OR = 1.05, 95% CI: 1.01-1.08). Exposure to phthalates (PAEs) increases the risk of MetS, with MECPP (OR = 1.16, 95% CI: 1.04-1.29) being an example. Moreover, polychlorinated biphenyls (PCBs) (OR = 1.47, 95% CI: 1.13-1.93) and organochlorine pesticides (OCPs) (OR = 1.97, 95% CI: 1.33-2.90) showed a positive association with the MetS. This study reveals that EEDs are a risk factor for MetS, which provides new evidence for the relationship between population EEDs exposure and MetS.
代谢综合征（MetS）被认为是导致慢性非传染性疾病风险增加的一个重要因素。研究发现，接触环境内分泌干扰物（EEDs）与代谢综合征有关，但两者之间的关系尚不清楚。为了阐明两者之间的关系，我们进行了一项系统综述和荟萃分析来研究它们之间的关联。我们检索了科学网数据库、Embase和PubMed。然后，我们利用I统计量评估文献的异质性，并根据PRISMA指南，使用固定效应模型（I<50%）和随机效应模型（I>50%）对数据进行合并。结果显示，接触全氟烷基物质（PFASs）与代谢综合征的特定组成部分有关，如全氟壬酸（PFNA）与“高腰围”（OR = 1.23，95%CI：1.10 - 1.38），以及全氟辛酸（PFOA）与“血压升高”（OR = 1.05，95%CI：1.01 - 1.08）。接触邻苯二甲酸酯（PAEs）会增加患代谢综合征的风险，例如邻苯二甲酸单（2-乙基己基）酯（MECPP）（OR = 1.16，95%CI：1.04 - 1.29）。此外，多氯联苯（PCBs）（OR = 1.47，95%CI：1.13 - 1.93）和有机氯农药（OCPs）（OR = 1.97，95%CI：1.33 - 2.90）与代谢综合征呈正相关。这项研究表明，环境内分泌干扰物是代谢综合征的一个风险因素，这为人群接触环境内分泌干扰物与代谢综合征之间的关系提供了新的证据。
