State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei 430030, China.
Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Sci Total Environ. 2023 Jun 15;877:162935. doi: 10.1016/j.scitotenv.2023.162935. Epub 2023 Mar 17.
Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are commonly detected in humans due to their persistence and bioaccumulation, and are suspected risk factors for metabolic syndrome (MetS). However, most studies have focused on individual rather than combined exposure. We explored the associations between individual and combined PCBs/OCPs exposure and MetS to better assess the health effects of PCBs and OCPs. This cross-sectional study included 1996 adults from Wuhan, China. A total of 338 participants fulfilled criteria for MetS. Eight PCBs and OCPs were detected in >50 % of the samples. Most of the hexachlorocyclohexanes (HCHs) in the serum were derived from the recent environmental input of lindane, while the high levels of dichlorodiphenyltrichloroethane (DDTs) were mainly due to historical use. Multivariate linear regression analyses revealed that β-HCH, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), PCB-52, PCB-153, and PCB-180 were positively correlated with increased odds of MetS. The profiles of the PCBs and OCPs associated with the different components of MetS were distinct. Furthermore, quantile-based g computation (qgcomp) analyses showed that PCB and OCP mixtures were positively associated with the risk of MetS, and p,p'-DDE was the largest contributor to our model. These findings suggest that PCB and OCP concentrations, both individually and as mixtures, are associated with MetS risk. Prospective studies are needed to confirm these results.
多氯联苯（PCBs）和有机氯农药（OCPs）由于其持久性和生物累积性，在人体中普遍存在，被怀疑是代谢综合征（MetS）的危险因素。然而，大多数研究都集中在单个污染物的暴露上，而不是组合暴露。我们探讨了个体和组合 PCB/OCP 暴露与代谢综合征之间的关系，以更好地评估 PCBs 和 OCPs 的健康影响。本横断面研究纳入了中国武汉的 1996 名成年人。共有 338 名参与者符合代谢综合征的标准。在>50%的样本中检测到 8 种 PCBs 和 OCPs。血清中大多数六氯环己烷（HCHs）来源于近期林丹的环境输入，而高水平的滴滴涕（DDTs）主要是由于历史上的使用。多变量线性回归分析显示，β-HCH、p,p'-二氯二苯二氯乙烯（p,p'-DDE）、PCB-52、PCB-153 和 PCB-180 与代谢综合征的发生风险呈正相关。与代谢综合征不同成分相关的 PCBs 和 OCPs 谱明显不同。此外，基于分位数的 g 计算（qgcomp）分析表明，PCB 和 OCP 混合物与代谢综合征的风险呈正相关，p,p'-DDE 是我们模型中最大的贡献者。这些发现表明，PCB 和 OCP 浓度无论是单独存在还是作为混合物，都与代谢综合征的风险相关。需要前瞻性研究来证实这些结果。
