Hassan Mohamed, Hojski Aljaz, Oliveira Leonel, Gahl Brigitta, Rüter Florian, Lardinois Didier
Department of Thoracic Surgery, University Hospital Basel, Basel, Switzerland.
Quality Management and Value Based Healthcare, University Hospital Basel, Basel, Switzerland.
J Thorac Dis. 2025 Jun 30;17(6):3727-3736. doi: 10.21037/jtd-2025-173. Epub 2025 Jun 19.
Surgical resection of early-stage non-small cell lung cancer (NSCLC) is associated with prolonged survival. However, there is a paucity of research investigating the long-term effects of the extent of lung resection on patients' quality of life. The aim of the study was to investigate the patient-reported outcome measures (PROMs) after thoracoscopic anatomic lung resection (lobar and sublobar) for NSCLC.
We conducted a retrospective analysis of prospectively collected PROMs following thoracoscopic anatomic lung resection (lobar and sublobar) for NSCLC stages I-IIA. The primary endpoint was the change in physical function scores at 3, 6, 12, and 24 months post-surgery. Secondary endpoints included changes in patient-reported shortness of breath and coughing scores post-surgery between the two resection types.
A total of 57 patients were included in this study, with 26 patients undergoing lobar resection and 31 undergoing sublobar resection. The mean age was 71.4±8.3 years in the lobar resection group and 70.7±10.5 years in the sublobar resection group (P=0.77). There were no significant differences in the preoperative lung function tests between the two groups [mean forced expiratory volume in the first second (FEV1) was 88%±17.1% in the lobar group and 83.4%±19.3% in the sublobar group, P=0.37]. The mean baseline physical functioning scores were 78±23 in the lobar group and 73±30 in the sublobar group (P=0.44). Changes in physical functioning scores did not differ significantly between lobar and sublobar resection groups (P=0.76) during the study period and up to 2 years after the surgery. Additionally, the type of lung resection had no effect on symptom scores for shortness of breath (P=0.24) or coughing (P=0.73).
Patient-reported physical function, shortness of breath, and coughing did not significantly change from 3 months to 2 years following thoracoscopic anatomical lung resection in patients with NSCLC. The type of lung resection (lobar or sublobar) also had no significant effect on these outcomes.
早期非小细胞肺癌（NSCLC）手术切除可延长生存期。然而，关于肺切除范围对患者生活质量的长期影响的研究较少。本研究的目的是调查非小细胞肺癌患者接受胸腔镜解剖性肺切除（肺叶和肺段）后的患者报告结局指标（PROMs）。
我们对前瞻性收集的I-IIA期非小细胞肺癌患者接受胸腔镜解剖性肺切除（肺叶和肺段）后的PROMs进行了回顾性分析。主要终点是术后3、6、12和24个月时身体功能评分的变化。次要终点包括两种切除类型术后患者报告的呼吸急促和咳嗽评分的变化。
本研究共纳入57例患者，其中26例行肺叶切除，31例行肺段切除。肺叶切除组的平均年龄为71.4±8.3岁，肺段切除组为70.7±10.5岁（P=0.77）。两组术前肺功能测试无显著差异[肺叶组第一秒用力呼气量（FEV1）平均为88%±17.1%，肺段组为83.4%±19.3%，P=0.37]。肺叶组的平均基线身体功能评分为78±23，肺段组为73±30（P=0.44）。在研究期间及术后2年内，肺叶和肺段切除组的身体功能评分变化无显著差异（P=0.76）。此外，肺切除类型对呼吸急促（P=0.24）或咳嗽（P=0.73）的症状评分没有影响。
非小细胞肺癌患者接受胸腔镜解剖性肺切除后3个月至2年，患者报告的身体功能、呼吸急促和咳嗽情况没有显著变化。肺切除类型（肺叶或肺段）对这些结局也没有显著影响。
