Wang Jiao-Man, Song Yin-Wei, Su Jing-Jing, Fu Li-Cheng, Gong Di, Guo Ping, Yang Wei-Hua
The 2nd Clinical Medical College of Jinan University, Shenzhen 518000, Guangdong Province, China.
Shenzhen People's Hospital (the Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China.
Int J Ophthalmol. 2025 Jul 18;18(7):1383-1397. doi: 10.18240/ijo.2025.07.23. eCollection 2025.
In recent years, Mendelian randomization (MR) has been increasingly utilized, leveraging genetic variants as instrumental variables. This approach significantly mitigates confounder effects and reverse causation, precisely clarifying the causal links between exposures and outcomes. MR's unique advantages have made it instrumental in medicine, especially in elucidating glaucoma's etiology. It facilitates the identification of potential risk factors, laying the groundwork for developing preventative and therapeutic strategies against glaucoma. Recent MR research has delved into diverse potential glaucoma risk factors, including behavioral habits, metabolic profiles, and their causative linkage to the disease. This review encapsulates MR's analysis in glaucoma etiology, heralding new avenues for understanding underlying mechanisms and establishing causality.
近年来，孟德尔随机化（MR）的应用越来越广泛，它利用基因变异作为工具变量。这种方法显著减轻了混杂因素的影响和反向因果关系，精确地阐明了暴露因素与结局之间的因果联系。MR的独特优势使其在医学领域发挥了重要作用，尤其是在阐明青光眼的病因方面。它有助于识别潜在的风险因素，为制定青光眼的预防和治疗策略奠定基础。最近的MR研究深入探讨了各种潜在的青光眼风险因素，包括行为习惯、代谢特征及其与该疾病的因果联系。本综述总结了MR在青光眼病因学中的分析，为理解潜在机制和确立因果关系开辟了新途径。
