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无刺蜂蜂蜜漱口水对牙菌斑积聚的影响:一项随机临床试验。

Effects of a Stingless Bee Honey Mouth Rinse on Dental Plaque Accumulation: A Randomised Clinical Trial.

作者信息

Reduan Misya Humaira, Zulkaflee Nor Suhaira, Sabarudin Muhammad Annurdin, Mat Baharin Nor Haliza, Nik Azis Nik Madihah, Abdul Hayei Nur Ayman

机构信息

Faculty of Dentistry, Universiti Sains Islam Malaysia, Kuala Lumpur, MYS.

Periodontology, Faculty of Dentistry, Universiti Sains Islam Malaysia, Kuala Lumpur, MYS.

出版信息

Cureus. 2025 Jun 18;17(6):e86307. doi: 10.7759/cureus.86307. eCollection 2025 Jun.

Abstract

Background Mouth rinses are recommended as an adjunct to mechanical methods in oral hygiene procedures for the prevention and management of periodontal diseases. The currently used mouth rinses impose several side effects on patients, which include a burning sensation and altered taste. Alternatively, stingless bee honey (SBH) is a natural food with many health benefits, making it suitable as an active mouth rinse ingredient. Several characteristics, such as antibacterial, anti-inflammatory, and healing properties, make it a potential therapeutic agent in periodontal therapy as well as in the oral cavity. This study aimed to investigate the ability of SBH mouth rinses to reduce plaque accumulation and to assess patient acceptance of their use. Methods This is a randomised pilot clinical trial performed on volunteers (N = 30) with healthy gingiva and/or mild gingivitis, who were randomly prescribed SBH, chlorhexidine (CHX), or normal saline (NS) mouth rinses, without oral hygiene practices for three days. Plaque scores were recorded prior to the experiment by a single examiner, blinded to the treatment allocation. Plaque accumulation and patient perception were recorded post-intervention using the plaque score and visual analogue scale (VAS), respectively.  Results At three days post-intervention, there was no significant difference in the plaque score of the SBH and NS groups (p > 0.05), compared to the baseline value. A significant decrease in the plaque score was found in the CHX group (p < 0.05), compared to the baseline. A significantly better taste and lower burning sensation were reported in the SBH group than in the NS and CHX groups, respectively. Conclusions The SBH mouth rinse did not promote plaque accumulation in the absence of oral hygiene and caused less burning sensation. CHX, however, has a greater ability to prevent plaque accumulation.

摘要

背景

漱口水被推荐作为口腔卫生程序中机械方法的辅助手段,用于预防和管理牙周疾病。目前使用的漱口水会给患者带来多种副作用,包括烧灼感和味觉改变。相比之下,无刺蜂蜂蜜(SBH)是一种具有多种健康益处的天然食品,使其适合作为活性漱口水成分。其抗菌、抗炎和愈合等多种特性,使其成为牙周治疗以及口腔中的潜在治疗剂。本研究旨在调查SBH漱口水减少牙菌斑积聚的能力,并评估患者对其使用的接受度。

方法

这是一项针对牙龈健康和/或轻度牙龈炎志愿者(N = 30)进行的随机试点临床试验,他们被随机开具SBH、氯己定(CHX)或生理盐水(NS)漱口水,且三天内不进行口腔卫生措施。在实验前由一名对治疗分配不知情的检查者记录牙菌斑分数。干预后分别使用牙菌斑分数和视觉模拟量表(VAS)记录牙菌斑积聚情况和患者感受。

结果

干预后三天,SBH组和NS组的牙菌斑分数与基线值相比无显著差异(p > 0.05)。与基线相比,CHX组的牙菌斑分数显著降低(p < 0.05)。SBH组报告的味觉明显优于NS组,烧灼感低于CHX组。

结论

在不进行口腔卫生措施的情况下,SBH漱口水不会促进牙菌斑积聚,且引起的烧灼感较小。然而,CHX预防牙菌斑积聚的能力更强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/450e/12274109/d35a41fabe14/cureus-0017-00000086307-i01.jpg

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