Oral Health Prev Dent. 2022 Jun 28;20:279-294. doi: 10.3290/j.ohpd.b3170043.
To summarise the available data on the effects of chlorhexidine (CHX) mouthwash in treating gingivitis during treatment with fixed orthodontic appliances.
Multiple electronic databases were searched up to December 7th, 2021. Only randomised controlled trials (RCTs) were eligible for inclusion. The quality of the included RCTs was assessed with the Cochrane risk of bias tool for randomised trials (RoB 2.0). After data extraction and risk of bias assessment, differences were recorded in several oral hygiene indices in time and mean percentage change in those indices using different antimicrobial solutions.
Fourteen studies were deemed eligible for inclusion, reporting on a total of 602 patients with an age range of 11-35 years. The experimental solution was a 0.06%, 0.12%, or 0.2% CHX mouthwash with the control either a placebo mouthwash or a selection from a variety of mouthwashes. Treatment duration varied from 1 day to almost 5 months and the follow-up period varied from 1 min to 5 months. Chlorhexidine mouthrinses led to reduced plaque accumulation and gingival inflammation during orthodontic treatment, while at the same time, some of the control group mouthrinses were deemed equally effective. No statistically significant difference was detected in the meta-analysis between CHX and mouthwashes with propolis/probiotics/herbs in terms of the gingival index at 3 to 4 weeks (mean difference 0.07, 95% CI: -0.18, 0.31, p = 0.59).
Chlorhexidine mouthwash in orthodontic patients successfully controls gingival inflammation and bleeding when compared to untreated controls, but is equally effective as other mouthrinses where various oral health indices are concerned.
总结在使用固定正畸矫治器治疗期间，洗必泰（CHX）漱口水治疗牙龈炎的现有数据。
从多个电子数据库中检索至 2021 年 12 月 7 日的文献。只有随机对照试验（RCT）才有资格纳入。使用 Cochrane 随机对照试验偏倚风险工具（RoB 2.0）评估纳入的 RCT 质量。在数据提取和偏倚风险评估后，记录了使用不同抗菌溶液时不同口腔卫生指标的时间差异和这些指标的平均百分比变化。
共有 14 项研究被认为符合纳入标准，共报告了 602 名年龄在 11-35 岁之间的患者。实验组的解决方案是 0.06%、0.12%或 0.2%的 CHX 漱口水，对照组为安慰剂漱口水或多种漱口水的选择。治疗持续时间从 1 天到近 5 个月不等，随访时间从 1 分钟到 5 个月不等。在正畸治疗期间，洗必泰漱口水可减少菌斑堆积和牙龈炎症，同时一些对照组漱口水被认为同样有效。在 3 至 4 周时，CHX 与含蜂胶/益生菌/草药的漱口水在牙龈指数方面的 meta 分析没有统计学差异（平均差异 0.07，95%CI：-0.18，0.31，p = 0.59）。
与未治疗的对照组相比，正畸患者使用洗必泰漱口水可成功控制牙龈炎症和出血，但在涉及各种口腔健康指标时，与其他漱口水同样有效。
