Radulescu Florin-Mihai, Nedea Ilie Marina Ionela, Dumitru Irina-Magdalena
Medicine, Doctoral School of Medicine, Ovidius University of Constanta, Constanta, ROU.
Pediatrician, "Marie Sklodowska Curie" Emergency Clinical Hospital for Children, Bucharest, ROU.
Cureus. 2025 Jun 20;17(6):e86413. doi: 10.7759/cureus.86413. eCollection 2025 Jun.
This study analyzes hematologic and inflammatory parameters in pediatric oncology patients with febrile neutropenia (FN) or sepsis, aiming to identify simple diagnostic markers. Conducted in a tertiary center, 150 infectious episodes were evaluated. Results showed statistically significant differences in leukocyte (G1: 4.95-7.03, p=0.01/G2: 4.91-7.01, p=0.01) and neutrophil counts (G1: 3.10-4.05, p=003/G2: 3.22-5.70, p=0.02) after treatment, especially in sepsis cases, with a statistically significant decrease in C-reactive protein (p=0.01) and procalcitonin (p=0.01) post-therapy. Although fibrinogen showed limited diagnostic value, the observed variation may still reflect a relevant pattern, as suggested in prior research. These findings highlight the importance of accessible biomarkers in guiding early diagnosis and management in resource-limited healthcare settings.
本研究分析了患有发热性中性粒细胞减少症（FN）或脓毒症的儿科肿瘤患者的血液学和炎症参数，旨在确定简单的诊断标志物。在一家三级中心进行了研究，评估了150次感染发作。结果显示，治疗后白细胞（G1：4.95 - 7.03，p = 0.01/G2：4.91 - 7.01，p = 0.01）和中性粒细胞计数（G1：3.10 - 4.05，p = 0.03/G2：3.22 - 5.70，p = 0.02）有统计学上的显著差异，尤其是在脓毒症病例中，治疗后C反应蛋白（p = 0.01）和降钙素原（p = 0.01）有统计学上的显著下降。尽管纤维蛋白原显示出有限的诊断价值，但观察到的变化仍可能反映出一种相关模式，正如先前研究所表明的那样。这些发现突出了可获取的生物标志物在资源有限的医疗环境中指导早期诊断和管理的重要性。
