抗癌药洛莫司汀与转谷氨酰胺酶催化位点的反应。
The reaction of the cancerostatic CCNU with the catalytic site of transglutaminase.
作者信息
Tarantino A, Thompson P
出版信息
Cancer Biochem Biophys. 1979;4(1):33-6.
PMID:40689
Abstract
The experiments in this paper show for the first time that CCNU, a nitrosourea, inhibits transglutaminase (an enzyme believed to be involved in tissue proliferation) on account of its cyclohexyl-isocyanate moiety.
摘要
本文中的实验首次表明，亚硝基脲类药物洛莫司汀因其环己基异氰酸酯部分而抑制转谷氨酰胺酶（一种被认为与组织增殖有关的酶）。
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