Idani Diba, Mashhadi Seyed Mohammadjavad, Babaei Hamze, Sharifipour Farideh, Nourinia Ramin, Kheiri Bahareh, Miraftabi Arezoo
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Ophthalmic Vis Res. 2025 May 19;20. doi: 10.18502/jovr.v20.15354. eCollection 2025.
To evaluate vascular changes on optical coherence tomography angiography (OCTA) in patients with diabetic macular ischemia (DMI) after systemic normobaric oxygen (NBO) therapy.
This before-after interventional studyincluded 26 eyes of 26 patients with DMI.Macular OCTA was performed before and after 1 hour of 100% NBO therapy at a flow of 10 L/min delivered by face mask. As primary outcomes, changes in OCTA metrics were evaluated using the paired -test. Subgroup analyses were performed based on gender. The secondary outcomes included identifying parameters correlated with best-corrected visual acuity (BCVA) and factors associated with improvement in OCTA parameters.
The patients included 15 males and 11 females aged 59.48 9.67 years. Overall, no significant change was observed in retinal thickness; however, there was a significant decrease in retinal thickness among females and a significant increase among males ( 0.001). The foveal avascular zone (FAZ) decreased significantly from 0.38 0.14 to 0.34 0.12 mm ( 0.035). Superficial capillary plexus vessel density (SCP-VD) and deep capillary plexus vessel density (DCP-VD) at fovea increased from 13.5 6.37 to 14.98 6.33% ( 0.059) and from 24.61 6.75 to 26.59 6.16% ( 0.022), respectively. In males, BCVA correlated significantly with baseline DCP parameters but corresponded with none of the SCP parameters. In females, BCVA significantly correlated with pre-O2 DCP-VD of the perifoveal inferior quadrant. Finally, regression analysis did not show any parameter that could predict a favorable response.
Using OCTA, we observed a decrease in FAZ and an increase in DCP-VD at fovea after short-term NBO therapy for patients with DMI.
评估全身常压氧（NBO）治疗后糖尿病性黄斑缺血（DMI）患者光学相干断层扫描血管造影（OCTA）上的血管变化。
这项前后对照的干预性研究纳入了26例DMI患者的26只眼。在通过面罩以10L/min的流速给予100%NBO治疗1小时前后进行黄斑OCTA检查。作为主要结局，使用配对t检验评估OCTA指标的变化。根据性别进行亚组分析。次要结局包括确定与最佳矫正视力（BCVA）相关的参数以及与OCTA参数改善相关的因素。
患者包括15名男性和11名女性，年龄为59.48±9.67岁。总体而言，视网膜厚度未观察到显著变化；然而，女性视网膜厚度显著降低，男性则显著增加（P<0.001）。中心凹无血管区（FAZ）从0.38±0.14显著减小至0.34±0.12mm（P=0.035）。中心凹处的浅表毛细血管丛血管密度（SCP-VD）和深部毛细血管丛血管密度（DCP-VD）分别从13.5±6.37增加至14.98±6.33%（P=0.059）和从24.61±6.75增加至26.59±6.16%（P=0.022）。在男性中，BCVA与基线DCP参数显著相关，但与任何SCP参数均无对应关系。在女性中，BCVA与中心凹下象限的吸氧前DCP-VD显著相关。最后，回归分析未显示任何可预测良好反应的参数。
使用OCTA，我们观察到DMI患者短期NBO治疗后FAZ减小，中心凹处DCP-VD增加。
