Shadravan Mahla, Yazdani Shahin, Kheiri Bahareh, Sharifipour Farideh, Doozandeh Azadeh, Hatami Mohammad Mehdi, Einollahi Neda
Clinical Research Development Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Ophthalmic Vis Res. 2025 May 5;20. doi: 10.18502/jovr.v20.15341. eCollection 2025.
Eyes with pseudoexfoliation demonstrate fragile intraocular structures. The current study evaluated conjunctival thickness in pseudoexfoliation eyes as compared to a control group.
In this cross-sectional study, patients with pseudoexfoliation and an age-matched control group underwent measurement of bulbar conjunctival thickness in the superior and temporal quadrants, 1, 2, and 3 mm posterior to the limbus using anterior segment OCT.
A total of 140 eyes of 140 subjects including 68 eyes of 68 patients with pseudoexfoliation and 72 eyes of 72 control subjects without pseudoexfoliation were studied. Both study groups were divided into two subgroups - those using glaucoma drops versus medication-free eyes. Total conjunctival thickness in pseudoexfoliation eyes was significantly lower than control eyes across all comparisons. Conjunctival thickness in the superior quadrant 1, 2, and 3 mm from the limbus was 177.62 41.30, 235 48.41, and 231.40 49.81 µm, respectively in the pseudoexfoliation group versus 207.49 48.92, 265.67 52.66, and 262.74 59.43 µm in the control group ( 0.001, 0.001, and 0.001, respectively). In the temporal quadrant, conjunctival thickness 1, 2, and 3 mm from the limbus was 193.62 46.97, 198.19 54.67, and 178.59 57.90 µm, respectively in the pseudoexfoliation group versus 213.76 47.06, 224.50 56.24, and 210.26 63.70 µm in the control group ( = 0.012, 0.006, and 0.003, respectively).
Conjunctival thickness was significantly less in pseudoexfoliation eyes than an age-matched control group which supports clinical observations of thinner and more fragile conjunctiva in these eyes with implications for glaucoma surgery.
假性剥脱综合征患者的眼内结构较为脆弱。本研究比较了假性剥脱综合征患者与对照组的结膜厚度。
在这项横断面研究中，假性剥脱综合征患者及年龄匹配的对照组接受了眼前节光学相干断层扫描，测量角膜缘后1、2和3毫米处上方和颞侧象限的球结膜厚度。
共研究了140名受试者的140只眼，其中包括68例假性剥脱综合征患者的68只眼和72例无假性剥脱综合征对照组受试者的72只眼。两个研究组均分为两个亚组——使用青光眼滴眼液组和未用药组。在所有比较中，假性剥脱综合征患者的结膜总厚度均显著低于对照组。假性剥脱综合征组角膜缘后1、2和3毫米处上方象限的结膜厚度分别为177.62±41.30、235±48.41和231.40±49.81微米，而对照组分别为207.49±48.92、265.67±52.66和262.74±59.43微米（P均<0.001）。在颞侧象限，假性剥脱综合征组角膜缘后1、2和3毫米处的结膜厚度分别为193.62±46.97、198.19±54.67和178.59±57.90微米，而对照组分别为213.76±47.06、224.50±56.24和210.26±63.70微米（P分别为0.012、0.006和0.003）。
假性剥脱综合征患者的结膜厚度显著低于年龄匹配的对照组；这支持了临床上观察到的这些患者结膜更薄且更脆弱的现象，这对青光眼手术具有重要意义。
