Motevasseli Tahmineh, Seraj Aryan, Daftarian Narsis, Kanav Mozhgan Rezaei, Ahmadieh Hamid, Sheibani Nader
Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Experimental Medicine, Department of Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada.
J Ophthalmic Vis Res. 2025 May 21;20. doi: 10.18502/jovr.v20.16966. eCollection 2025.
Treatment of posterior segment fibrosis is an unmet challenge in ophthalmology. Fibrotic responses complicate the pathology and treatment of age-related macular degeneration, diabetic retinopathy, retinal detachment, and other retinal diseases resulting in severe visual impairment. There is a lack of clear understanding of the exact mechanisms and different cell types taking part in retinal and preretinal fibrosis. This review discusses the current knowledge regarding various aspects of the intracellular signaling pathways impacting vitreoretinal fibrotic processes, focusing on the cellular and molecular mechanisms, summarizing the results of preclinical and clinical studies, and suggesting strategies for future investigations.
后段纤维化的治疗是眼科领域尚未解决的挑战。纤维化反应使年龄相关性黄斑变性、糖尿病视网膜病变、视网膜脱离及其他视网膜疾病的病理和治疗变得复杂，导致严重视力损害。目前对于参与视网膜和视网膜前纤维化的确切机制及不同细胞类型尚缺乏清晰认识。本综述讨论了关于影响玻璃体视网膜纤维化过程的细胞内信号通路各方面的现有知识，重点关注细胞和分子机制，总结临床前和临床研究结果，并提出未来研究策略。
