Loginov V M, Krimker V M
Med Radiol (Mosk). 1985 Nov;30(11):29-31.
Experiments were staged on rats with transplantable anaplastic cerebral right hemisphere astrocytomas. Hyperglycemia was induced by means of intraperitoneal fractional administration of 40% glucose solution. Single local x-ray tumor irradiation followed on the 4-5th, 7-8th and 10-12th days after strain transplantation at the doses of 30 and 40 Gy without hyperglycemia and in combination with it. The irradiation effect was assessed by the mean survival time of the animals. Hyperglycemia was shown to increase significantly radiation injury of highly resistant experimental malignant cerebral glial tumors.
对患有可移植间变性脑右半球星形细胞瘤的大鼠进行了实验。通过腹腔分次注射40%葡萄糖溶液诱导高血糖。在肿瘤移植后的第4 - 5天、第7 - 8天和第10 - 12天，分别以30 Gy和40 Gy的剂量对肿瘤进行单次局部X射线照射，照射时分为无高血糖组和合并高血糖组。通过动物的平均存活时间评估照射效果。结果表明，高血糖会显著增加高抗性实验性恶性脑胶质瘤的放射损伤。
