Loginov V M, Gnezditskiĭ V V, Emeliushina O N, Mukhamedzhanov N Z
Med Radiol (Mosk). 1991;36(2):26-8.
The paper is concerned with the results of investigation of the effect of short-term hyperglycemia on main cerebral functions in neuro-oncological patients. Clinical and paraclinical control in the course of investigation revealed insignificant and transient changes of the neurological status, ECG and investigated cerebral functions. In a lesser group of patients changes over time were unobserved. Taking into account good tolerance of short-term hyperglycemia and the results of its effective use in general oncology, one can recommend it as a modifier in radiation therapy of brain gliomas. Proceeding from the obtained experimental data on a similar tumor model as well as positive results of the use of short-term hyperglycemia in general oncology, its use appeared to be most effective after tumor irradiation. Taking into account a certain degree of unreliability of the method (catheterization of the subclavicular vein), requiring strict control on the part of medical personnel, the use of short-term hyperglycemia could be effectively implemented during large-fractionated irradiation of brain gliomas.
本文关注短期高血糖对神经肿瘤患者主要脑功能影响的研究结果。研究过程中的临床和辅助临床检查显示，神经状态、心电图及所研究的脑功能仅有轻微且短暂的变化。在较少一部分患者中未观察到随时间的变化。考虑到短期高血糖的良好耐受性及其在普通肿瘤学中的有效应用结果，可推荐将其作为脑胶质瘤放射治疗的一种修饰剂。基于在类似肿瘤模型上获得的实验数据以及短期高血糖在普通肿瘤学中的积极应用结果，其在肿瘤照射后使用似乎最为有效。考虑到该方法（锁骨下静脉置管）存在一定程度的不可靠性，需要医务人员严格把控，短期高血糖的应用可在脑胶质瘤大分割照射期间有效实施。
