Cheng Hua, Hou Qiufei, Peng Dayong, Wang Dawei
School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
School of Food Science and Chemical Engineering, Hubei University of Arts and Science, Xiangyang 441053, China.
Org Biomol Chem. 2025 Aug 6;23(31):7221-7243. doi: 10.1039/d5ob00931f.
Neopeltolide, a macrolide natural product of marine origin, was initially isolated from a deep-sea sponge belonging to the Neopeltidae family. This compound has garnered significant attention due to its intriguing structural complexity and remarkable biological potency. Since its discovery, the scientific community has reported over twenty distinct total syntheses, formal syntheses, and fragment syntheses of this natural product, along with developing more than eighty neopeltolide analogues with their corresponding biological evaluations. This comprehensive review systematically examines the biological profile of neopeltolide and elucidates its structure-activity relationships. We provide a detailed overview of the synthetic approaches and biological evaluations of neopeltolide and its structural analogs, with particular emphasis on the synthetic efforts that have contributed to understanding its structure-activity relationship.
新软海绵内酯是一种源自海洋的大环内酯类天然产物，最初是从属于新软海绵科的一种深海海绵中分离出来的。该化合物因其引人入胜的结构复杂性和卓越的生物活性而备受关注。自发现以来，科学界已报道了该天然产物的二十多种不同的全合成、形式合成和片段合成方法，同时还开发了八十多种新软海绵内酯类似物并进行了相应的生物学评估。这篇综述系统地研究了新软海绵内酯的生物学特性，并阐明了其构效关系。我们详细概述了新软海绵内酯及其结构类似物的合成方法和生物学评估，特别强调了有助于理解其构效关系的合成研究。
