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新片螺素，一种从片螺科石海绵中提取的大环内酯类化合物。

Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.

作者信息

Wright Amy E, Botelho Julianne Cook, Guzmán Esther, Harmody Dedra, Linley Patricia, McCarthy Peter J, Pitts Tara P, Pomponi Shirley A, Reed John K

机构信息

Center for Ocean Exploration, Biomedical Marine Research Program, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, FL 34946, USA.

出版信息

J Nat Prod. 2007 Mar;70(3):412-6. doi: 10.1021/np060597h. Epub 2007 Feb 20.

DOI:10.1021/np060597h

PMID:17309301

Abstract

A new marine-derived macrolide designated as neopeltolide (1) has been isolated from a deep-water sponge of the family Neopeltidae. Its structure was elucidated on the basis of spectroscopic data interpretation. Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively. Neopeltolide (1) also inhibited the growth of the fungal pathogen Candida albicans with a minimum inhibitory concentration of 0.62 microg/mL.

摘要

一种新的源自海洋的大环内酯类化合物，命名为新皮海绵内酯（1），已从新皮海绵科的一种深水海绵中分离出来。其结构是根据光谱数据解释确定的。新皮海绵内酯（1）是A-549人肺腺癌、NCI-ADR-RES人卵巢肉瘤和P388小鼠白血病细胞系体外增殖的有效抑制剂，其IC50分别为1.2、5.1和0.56 nM。新皮海绵内酯（1）还抑制真菌病原体白色念珠菌的生长，最低抑菌浓度为0.62μg/mL。