Low Bryant, Lizwan Marco, Tan Sarah, Ng Cindy, Chu Irene, Lee Zhen Jin, Eng Alvin, Lim Eugene, Chan Weng Hoong, Tan Jeremy, Tan Hong Chang, Ho Emily, Kovalik Jean-Paul, Goh Orlanda, Sim Jacqueline, Lee Phong Ching, Lim Chin Hong
Singapore General Hospital, Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.
Obes Surg. 2025 Jul 21. doi: 10.1007/s11695-025-08015-z.
Bariatric-metabolic surgery (BMS) reduces muscle mass due to rapid weight loss. The objective is to assess the prevalence of pre-operative low muscle strength and predictors of post-operative low muscle strength in Asian populations undergoing BMS.
This observational study included BMS patients from a single centre between January 2022 and May 2024. Baseline demographics, anthropometric data and pre-operative muscle strength (via handgrip strength, 30-s and 1-min sit-to-stand-test) were collected. Low muscle strength was diagnosed using age-, sex- and ethnicity-specific cutoffs. Post-operative outcomes included hospital stay duration, 30-day adverse events, weight loss and strength at 6 months.
Three hundred twenty-four participants were included (96 male, mean age 39.2 years, mean pre-op BMI 42.3), with low muscle strength observed in 162 (50%). This group had a higher pre-operative BMI compared to the normal muscle strength group (43.5 vs 41.0, p = 0.002). Indian participants had the highest prevalence of low muscle strength (p = 0.043). There were no significant differences in age, sex and biochemical markers between the groups. Post-operatively, there were no significant differences in complications and length of stay between the groups. At 6 months, 60.4% maintained muscle strength, while 14.2% showed a ≥ 10% decline. Adjusting for age, gender, pre-operative BMI and surgery type, higher pre-operative BMI was significantly associated with muscle strength drop of ≥ 10%.
Low muscle strength was prevalent in 50% of Asian BMS candidates, with higher BMI and Indian ethnicity identified as potential associated factors. In a subset with follow-up data, higher BMI predicted strength loss ≥ 10% post-operatively. Further longitudinal studies with validated strength measures are needed to confirm these associations.
减重代谢手术（BMS）会因体重快速下降导致肌肉量减少。目的是评估接受BMS的亚洲人群术前低肌肉力量的患病率以及术后低肌肉力量的预测因素。
这项观察性研究纳入了2022年1月至2024年5月来自单一中心的BMS患者。收集了基线人口统计学、人体测量数据和术前肌肉力量（通过握力、30秒和1分钟坐立试验）。使用年龄、性别和种族特异性切点诊断低肌肉力量。术后结果包括住院时间、30天不良事件、体重减轻和6个月时的力量。
纳入了324名参与者（96名男性，平均年龄39.2岁，术前平均BMI 42.3），其中162名（50%）观察到低肌肉力量。与正常肌肉力量组相比，该组术前BMI更高（43.5对41.0，p = 0.002）。印度参与者低肌肉力量的患病率最高（p = 0.043）。两组之间在年龄、性别和生化指标方面无显著差异。术后，两组之间在并发症和住院时间方面无显著差异。6个月时，60.4%的人保持了肌肉力量，而14.2%的人下降了≥10%。调整年龄、性别、术前BMI和手术类型后，较高的术前BMI与肌肉力量下降≥10%显著相关。
50%的亚洲BMS候选者存在低肌肉力量，较高的BMI和印度种族被确定为潜在相关因素。在有随访数据的亚组中，较高的BMI预测术后力量下降≥10%。需要进一步进行具有有效力量测量的纵向研究来证实这些关联。
