Husain Atif, Kushwaha Poonam, Kapoor Archita, Singh Priyanka
Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, 226026, India.
AAPS PharmSciTech. 2025 Jul 21;26(7):195. doi: 10.1208/s12249-025-03188-3.
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes and immune dysregulation, leading to erythematous, scaly plaques. Conventional treatments, including corticosteroids, immunosuppressants, and biologics, often present challenges such as systemic side effects, poor skin penetration, and reduced patient compliance. Lipid nanocarriers (LNCs) have emerged as promising drug delivery systems for psoriasis management, offering enhanced drug stability, targeted delivery, improved skin penetration, and controlled drug release. This review explores the advancements in LNC-based formulations, including solid lipid nanoparticles, nanostructured lipid carriers, liposomes, and ethosomes, highlighting their advantages over traditional therapies. The physicochemical properties, mechanisms of skin penetration, and therapeutic efficacy of LNCs in psoriasis treatment are discussed, along with preclinical and clinical findings. The integration of lipid nanocarriers into psoriasis treatment regimens holds significant promise for improving patient outcomes by providing more effective and safer therapeutic alternatives.
银屑病是一种慢性炎症性皮肤病，其特征为角质形成细胞过度增殖和免疫失调，导致出现红斑、鳞屑性斑块。包括皮质类固醇、免疫抑制剂和生物制剂在内的传统治疗方法常常存在全身副作用、皮肤渗透性差以及患者依从性降低等挑战。脂质纳米载体（LNCs）已成为用于银屑病治疗的有前景的药物递送系统，具有增强的药物稳定性、靶向递送、改善的皮肤渗透性和可控的药物释放。本综述探讨了基于LNCs的制剂的进展，包括固体脂质纳米粒、纳米结构脂质载体、脂质体和醇质体，强调了它们相对于传统疗法的优势。讨论了LNCs在银屑病治疗中的物理化学性质、皮肤渗透机制和治疗效果，以及临床前和临床研究结果。将脂质纳米载体整合到银屑病治疗方案中，通过提供更有效、更安全的治疗选择，有望显著改善患者的治疗效果。
