Gao Yujie, Xu Tianqi, Wang Yu, Hu Yanjinhui, Yin Shaoping, Qin Zhiguo, Yu Hua
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
Department of Pharmacy, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Pharmaceutics. 2025 Jan 3;17(1):56. doi: 10.3390/pharmaceutics17010056.
Psoriasis, a chronic inflammatory dermatosis, represents a significant clinical challenge due to its complex pathogenesis and the limitations of existing therapeutic strategies. Current psoriasis diagnoses are primarily clinician-dependent, with instrumental diagnostics serving as adjuncts. Ongoing research is progressively deciphering its molecular underpinnings; the future of psoriasis diagnostics may involve genetic and immunological profiling to pinpoint biomarkers, enabling more accurate and timely interventions. The administration of psoriasis medications, whether oral, injectable, or topical, is associated with a range of side effects and compliance issues. Topical medications, despite their advantages in patient compliance and reduced systemic side effects, are hindered by the altered skin barrier in psoriasis, which impedes effective drug penetration and retention. In recent years, the development of novel transdermal drug delivery systems represents a promising frontier in psoriasis management. Nanotechnology-, microneedle- and dressing-based systems have demonstrated the potential for improved skin penetration, enhanced bioavailability, or extended retention time. Here, we will focus on the latest insights into the etiology, diagnostic methodologies, and therapeutic approaches for psoriasis, with a particular emphasis on the evolution and challenges of novel transdermal drug delivery systems.
银屑病是一种慢性炎症性皮肤病，由于其发病机制复杂且现有治疗策略存在局限性，构成了重大的临床挑战。目前银屑病的诊断主要依赖临床医生，仪器诊断仅作为辅助手段。正在进行的研究正逐步揭示其分子基础；银屑病诊断的未来可能涉及基因和免疫分析以确定生物标志物，从而实现更准确、及时的干预。银屑病药物的给药方式，无论是口服、注射还是外用，都存在一系列副作用和依从性问题。外用药物尽管在患者依从性和减少全身副作用方面具有优势，但因银屑病患者皮肤屏障改变，阻碍了药物的有效渗透和留存。近年来，新型透皮给药系统的开发是银屑病治疗领域一个有前景的前沿方向。基于纳米技术、微针和敷料的系统已显示出改善皮肤渗透、提高生物利用度或延长留存时间的潜力。在此，我们将聚焦于银屑病病因、诊断方法和治疗途径的最新见解，尤其着重于新型透皮给药系统的发展与挑战。
