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用于下睑退缩手术矫正的真皮与耳廓软骨移植的比较前瞻性研究

A Comparative Prospective Study of Dermis versus Auricular Cartilage Grafts for the Surgical Correction of Lower Eyelid Retraction.

作者信息

Dias Gumiero Mariana P L, Beltrão Lissa, Monteiro Mário L R, Pieroni Gonçalves Allan C

机构信息

Division of Ophthalmology and the Laboratory for Investigation in Ophthalmology (LIM-33), University of São Paulo Medical School, São Paulo, Brazil.

出版信息

Aesthetic Plast Surg. 2025 Jul 21. doi: 10.1007/s00266-025-04995-6.

Abstract

BACKGROUND

Lower eyelid retraction (LER) affects both aesthetics and eye function, often resulting from surgery, Graves' orbitopathy, or aging. Various grafting techniques are employed in its correction.

OBJECTIVES

This study aimed to compare the efficacy of autologous dermis and auricular cartilage grafts in treating LER, with primary focus on changes in margin reflex distance 2 (MRD2).

METHODS

This prospective, randomized interventional study included 26 patients with stable LER. Patients were randomly assigned to receive either auricular cartilage or dermis grafts in surgical correction, using a 2-mm graft: 1 mm scleral show ratio. MRD2 measurements were taken preoperatively and at several postoperative intervals, with complications and outcomes recorded.

RESULTS

The study included 35 eyelids from 20 patients, split evenly between the two graft groups. A significant improvement in MRD2 was observed in both groups post-surgery. Group 1 (cartilage) showed a 10% MRD2 increase over six months, while Group 2 (dermis) showed an 18% increment. Complication rates were low, with seven eyelids in the cartilage group developing granulomas. No persistent keratopathy or infection was noted. Dermis grafts exhibited no cysts or contour issues.

CONCLUSIONS

Both graft types were effective for LER treatment, with dermis grafts showing fewer complications and quicker recovery. Recommendations for graft height adjustment may enhance outcomes, particularly in severe cases. Additional techniques like midface elevation could improve results. Further research with a larger sample size is warranted to confirm these findings.

LEVEL OF EVIDENCE I

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

摘要

背景

下睑退缩(LER)会影响美观和眼部功能,通常由手术、格雷夫斯眼眶病或衰老引起。其矫正采用了多种移植技术。

目的

本研究旨在比较自体真皮和耳廓软骨移植治疗LER的疗效,主要关注边缘反射距离2(MRD2)的变化。

方法

这项前瞻性、随机干预研究纳入了26例LER稳定的患者。患者被随机分配在手术矫正中接受耳廓软骨或真皮移植,采用2毫米移植片:1毫米巩膜暴露比例。术前及术后多个时间点进行MRD2测量,并记录并发症和结果。

结果

该研究纳入了来自20例患者的35只眼睑,平均分为两个移植组。两组术后MRD2均有显著改善。第1组(软骨)在6个月内MRD2增加了10%,而第2组(真皮)增加了18%。并发症发生率较低,软骨组有7只眼睑出现肉芽肿。未发现持续性角膜病变或感染。真皮移植未出现囊肿或轮廓问题。

结论

两种移植类型对LER治疗均有效,真皮移植并发症更少且恢复更快。移植高度调整的建议可能会改善结果,尤其是在严重病例中。如中面部提升等其他技术可能会改善效果。有必要进行更大样本量的进一步研究以证实这些发现。

证据水平I:本刊要求作者为每篇文章指定证据水平。有关这些循证医学评级的完整描述,请参阅目录或在线作者指南www.springer.com/00266

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