Extracellular volume fraction quantification by equilibrium contrast-enhanced CT via automated segmentation predicts survival outcomes in bladder cancer: a propensity score-matched study.

BACKGROUND

Extracellular volume fraction (ECV) is the unoccupied space or volume of tissue that is not occupied by cells and can be used to assess the growth and invasive behavior of solid tumors. Our study aimed to investigate the ability of extracellular volume fraction in predicting the prognosis of BLCA patients.

MATERIALS AND METHODS

A retrospective study recruited 319 BLCA patients who underwent surgery. The average CT value was recorded by creating 3D masks of the tumor and blood vessels, which was then used to calculate the preoperative ECV. A propensity score matching (PSM) was performed at a ratio of 1:1 to balance the baseline characteristics between the two groups. Correlations between ECV scores and pathological T stage (whether muscle invasion was present) were determined by using Pearson correlation coefficients. The effects of clinical or pathologic prognostic factors and ECV on recurrence-free survival (RFS), overall survival (OS) were assessed by univariate and multivariate analyses using Cox proportional risk models.

RESULTS

The 319 patients were divided into two groups, ECV-lower group ( = 178) and ECV-higher group ( = 141). After PSM analysis, patients in the ECV-lower group ( = 121) and patients in the ECV-higher group ( = 141) were obtained. In multivariate analysis, ECV was the independent prognostic factor for RFS (ECV-higher: HR: 2.55, 95% Cl: 1.85 to 3.51,  < 0.01), and for OS (ECV-higher: HR: 5.46, 95% Cl, 1.89 to 15.73,  = 0.02). A positive correlation between ECV and pathologic T stage was found both before and after PSM ( = 0.225,  < 0.001;  = 0.136,  = 0.028).

CONCLUSION

ECV can be used as a noninvasive biomarker to assist in the prognostic assessment of BLCA patients. Higher preoperative ECV indicates a poor prognosis for BLCA and requires aggressive treatment.