Kopecny Lucy, White Joanna D
Small Animal Specialist Hospital North Ryde, North Ryde, New South Wales, Australia.
J Vet Intern Med. 2025 Jul-Aug;39(4):e70187. doi: 10.1111/jvim.70187.
The prevalence of immune complex-mediated glomerulonephropathy (ICGN) in dogs with proteinuric kidney disease is approximately 50% in the United States and Europe but is unknown in other locations such as Australia and New Zealand.
Determine the prevalence of ICGN in dogs biopsied for proteinuric kidney disease in Australia and New Zealand and compare clinicopathologic variables in dogs with specific pathologic lesions.
Fifty client-owned dogs.
Retrospective case series. Reports from renal biopsy samples submitted to the Texas and International Veterinary Renal Pathology Services from dogs with proteinuric kidney disease (urine protein-to-creatinine ratio ≥ 0.5) between 2007 and 2023 were reviewed. Clinical data were retrieved and compared.
Among 50 dogs with proteinuric renal disease, 15 dogs (30%) had ICGN and 35 (70%) had non-ICGN. The most common category of ICGN was membranous glomerulonephropathy (6/15; 40%). Glomerulosclerosis was the most common category of non-ICGN (17/35; 49%). Dogs with glomerulosclerosis (median, 10 years) were older than dogs with other types of lesions (membranoproliferative, mesangioproliferative or mixed pattern; median, 6 years; p = 0.04) and those with membranous glomerulonephropathy (median, 4 years; p = 0.005). Dogs with membranous glomerulonephropathy had lower serum albumin concentrations (median, 2.1 g/dL) than dogs with glomerulosclerosis (median, 3.0 g/dL; p = 0.01) or other nephropathies (median, 3.0 g/dL; p = 0.04).
The prevalence of ICGN is lower in dogs in Australia and New Zealand biopsied for proteinuric kidney disease, potentially because of a lower prevalence of infectious disease, particularly vector-borne disease. The lower prevalence of ICGN emphasizes the importance of renal biopsy to optimize treatment.
在美国和欧洲，蛋白尿性肾病犬中免疫复合物介导的肾小球肾炎（ICGN）的患病率约为50%，但在澳大利亚和新西兰等其他地区尚不清楚。
确定澳大利亚和新西兰因蛋白尿性肾病接受活检的犬中ICGN的患病率，并比较具有特定病理病变的犬的临床病理变量。
50只客户拥有的犬。
回顾性病例系列研究。对2007年至2023年间提交给德克萨斯州和国际兽医肾脏病理服务机构的蛋白尿性肾病犬（尿蛋白与肌酐比值≥0.5）的肾活检样本报告进行了回顾。检索并比较了临床数据。
在50只蛋白尿性肾病犬中，15只（30%）患有ICGN，35只（70%）患有非ICGN。ICGN最常见的类型是膜性肾小球肾炎（6/15；40%）。肾小球硬化是最常见的非ICGN类型（17/35；49%）。患有肾小球硬化的犬（中位数，10岁）比患有其他类型病变（膜增生性、系膜增生性或混合模式）的犬（中位数，6岁；p = 0.04）以及患有膜性肾小球肾炎的犬（中位数，4岁；p = 0.005）年龄更大。患有膜性肾小球肾炎的犬血清白蛋白浓度（中位数，2.1g/dL）低于患有肾小球硬化的犬（中位数，3.0g/dL；p = 0.01）或其他肾病的犬（中位数，3.0g/dL；p = 0.04）。
在澳大利亚和新西兰因蛋白尿性肾病接受活检的犬中ICGN的患病率较低，这可能是由于传染病，特别是媒介传播疾病的患病率较低。ICGN的较低患病率强调了肾活检对优化治疗的重要性。
