Aktifah Nurul, Faradisi Firman, Setyawan Muhammad Ghilang Maulud, Fajriyah Nuniek Nizmah, Mugiyanto Eko, Rahayu Umi Budi
Undergraduate Program in Nursing University of Muhammadiyah Pekajangan Pekalongan Pekalongan Indonesia Indonesia.
Vocational Program in Nursing University of Muhammadiyah Pekajangan Pekalongan Pekalongan Indonesia Indonesia.
Health Sci Rep. 2025 Jul 20;8(7):e70919. doi: 10.1002/hsr2.70919. eCollection 2025 Jul.
Peripheral artery disease (PAD) is a common complication among diabetic neuropathy patients, often associated with abnormalities in thrombocyte indices. This study aimed to assess the impact of neuromuscular taping (NMT) on thrombocyte indices in diabetic neuropathy patients with PAD.
A total of 23 patients diagnosed with DN using the Toronto Clinical Neuropathy Scoring System (TCNSS) and Diabetic Neuropathy Examination (DNE) were enrolled in the study. Participants underwent NMT decompression intervention sessions over a period of 24 days. Further, the genomic analysis utilized public databases derived from diabetes studies that investigated the development of diabetic neuropathy.
The result revealed, pre- and post-intervention measurements demonstrated significant improvements in thrombocyte indices, particularly in platelet distribution width, platelet count, and mean platelet volume, among patients undergoing NMT ( < 0.05). Additionally, there was a notable decrease in TCNSS and DNE scores post-intervention, indicating an improvement in DN symptoms. Moreover, genomic analysis identified 9 genes, including SLC30A1, TRBJ2-7, OLFM1, TCF7L2, MCF2L, CEP295NL, CEACAM22P, TSHZ2, and PDZD4, involved in DN development.
These findings suggest that NMT holds promise as a therapeutic intervention for improving thrombocyte indices and managing DN symptoms in patients with PAD. Further research is warranted to elucidate the underlying mechanisms and long-term effects of NMT in this population.
外周动脉疾病（PAD）是糖尿病神经病变患者常见的并发症，常与血小板指标异常相关。本研究旨在评估神经肌肉贴扎术（NMT）对合并PAD的糖尿病神经病变患者血小板指标的影响。
共有23例使用多伦多临床神经病变评分系统（TCNSS）和糖尿病神经病变检查（DNE）诊断为糖尿病神经病变的患者纳入本研究。参与者在24天内接受了NMT减压干预疗程。此外，基因组分析利用了来自糖尿病研究的公共数据库，这些研究调查了糖尿病神经病变的发展情况。
结果显示，干预前后的测量结果表明，接受NMT的患者血小板指标有显著改善，尤其是血小板分布宽度、血小板计数和平均血小板体积（<0.05）。此外，干预后TCNSS和DNE评分显著降低，表明糖尿病神经病变症状有所改善。此外，基因组分析确定了9个与糖尿病神经病变发展相关的基因，包括SLC30A1、TRBJ2-7、OLFM1、TCF7L2、MCF2L、CEP295NL、CEACAM22P、TSHZ2和PDZD4。
这些发现表明，NMT有望作为一种治疗干预手段，用于改善合并PAD患者的血小板指标和控制糖尿病神经病变症状。有必要进一步研究以阐明NMT在该人群中的潜在机制和长期影响。
