The avoidance of mistakes by humans is achieved through continuous learning, error correction, and experience accumulation. This process is known to be both time-consuming and laborious, often involving numerous detours. In order to assist humans in their learning endeavors, ChatGPT (Generative Pre-trained Transformer) has been developed as a collection of large language models (LLMs) capable of generating responses that resemble human-like answers to a wide range of problems. In this study, we sought to assess the potential of LLMs as assistants in addressing queries related to orbital diseases. To accomplish this, we gathered a dataset consisting of 100 orbital questions, along with their corresponding answers, sourced from examinations administered to ophthalmologist residents and medical students. Five language models (LLMs) were utilized for testing and comparison purposes, namely, GPT-4, GPT-3.5, PaLM2, Claude 2, and SenseNova. Subsequently, the LLM exhibiting the most exemplary performance was selected for comparison against ophthalmologists and medical students. Notably, GPT-4 and PaLM2 demonstrated a superior average correlation when compared to the other LLMs. Furthermore, GPT-4 exhibited a broader spectrum of accurate responses and attained the highest average score among all the LLMs. Additionally, GPT-4 demonstrated the highest level of confidence during the test. The performance of GPT-4 surpassed that of medical students, albeit falling short of that exhibited by ophthalmologists. In contrast, the findings of the study indicate that GPT-4 exhibited superior performance within the orbital domain of ophthalmology. Given further refinement through training, LLMs possess considerable potential to be utilized as comprehensive instruments alongside medical students and ophthalmologists.