Nguyen Madison A, Lee Sarah S, Walsh Craig M
Molecular Biology and Biochemistry Department, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, United States.
Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Front Immunol. 2025 Jul 7;16:1613230. doi: 10.3389/fimmu.2025.1613230. eCollection 2025.
Regulatory T cells are essential for suppressing an overactive immune system, especially concerning autoimmune disease, tumor growth, and inflammatory disease. This suppressive nature of regulatory T cells is largely due to their metabolic profiles determined by metabolic reprogramming upon activation and subsequent differentiation. As regulatory T cells tend to process and cycle energy differently from other T cell subsets, we are interested in what metabolic processes support regulatory T cell function. This review will consider how regulatory T cells compare with conventional T cells in terms of their participation in distinct metabolic pathways and how the presence of regulatory T cell-specific molecules influences proliferation and suppressive function. Additionally, this review will identify possible metabolic targets of regulatory T cells that could be targeted for development of autoimmune disease therapies.
调节性T细胞对于抑制过度活跃的免疫系统至关重要，尤其是在自身免疫性疾病、肿瘤生长和炎症性疾病方面。调节性T细胞的这种抑制特性很大程度上归因于其代谢特征，这些特征由激活和随后分化时的代谢重编程所决定。由于调节性T细胞处理和循环能量的方式往往与其他T细胞亚群不同，我们对支持调节性T细胞功能的代谢过程感兴趣。本综述将探讨调节性T细胞与传统T细胞在参与不同代谢途径方面的比较，以及调节性T细胞特异性分子的存在如何影响增殖和抑制功能。此外，本综述将确定调节性T细胞可能的代谢靶点，这些靶点可用于开发自身免疫性疾病治疗方法。
