Song Guangyao, Xie Yuxiao, Yi Lanlan, Cheng Wenjie, Jia Huijin, Shi Wenzhe, Liu Qiwei, Fang Ligui, Xue Shiqi, Liu Dan, Zhu Junhong, Zhao Sumei
College of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.
College of Biology and Agriculture, Zunyi Normal University, Zunyi, China.
Front Med (Lausanne). 2025 Jul 7;12:1607899. doi: 10.3389/fmed.2025.1607899. eCollection 2025.
Bile acids play a dual role by aiding lipid absorption and acting as signaling molecules by interacting with various receptors. Bile acids are perpetually recycled via enterohepatic circulation and are biotransformation by gut microbiota, making bile acid metabolism a critical regulator of intestinal homeostasis. The intestinal epithelium prominently expresses two key bile acid receptors - the farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5) - which play indispensable roles in maintaining bile acid homeostasis and intestinal barrier function. Due to the abundant expression of bile acid receptors and the importance of the intestine in preventing pathogen invasion, researchers are increasingly focused on the function of bile acids in this system. This article focuses on the effect of bile acids and their receptors, FXR and the TGR5, in modulating intestinal barrier function.
胆汁酸通过辅助脂质吸收以及与各种受体相互作用充当信号分子，发挥双重作用。胆汁酸通过肠肝循环不断循环，并由肠道微生物群进行生物转化，使得胆汁酸代谢成为肠道内环境稳态的关键调节因子。肠上皮细胞显著表达两种关键的胆汁酸受体——法尼醇X受体（FXR）和G蛋白偶联胆汁酸受体1（TGR5），它们在维持胆汁酸稳态和肠道屏障功能中发挥着不可或缺的作用。由于胆汁酸受体的大量表达以及肠道在预防病原体入侵中的重要性，研究人员越来越关注胆汁酸在该系统中的功能。本文重点探讨胆汁酸及其受体FXR和TGR5在调节肠道屏障功能方面的作用。
