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从开颅手术到剖宫产:孕期脑膜瘤的多学科治疗方法

From Craniotomy to Caesarean: A Multidisciplinary Approach to Meningioma During Pregnancy.

作者信息

Adam Mohammedelfateh, Jothi Joshil Selva, Botros Karim, Khalid Azriny

机构信息

Obstetrics and Gynaecology, University Hospital Galway, Galway, IRL.

Obstetrics and Gynaecology, Cork University Maternity Hospital, Cork, IRL.

出版信息

Cureus. 2025 Jun 21;17(6):e86469. doi: 10.7759/cureus.86469. eCollection 2025 Jun.

DOI:10.7759/cureus.86469
PMID:40693084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12277926/
Abstract

This case report addresses a brain tumour - specifically, a meningioma - occurring during pregnancy. It describes the initial diagnosis, management, and outcome of a woman in her early 40s. She is para 2, and at 24 weeks + 3 days' gestation, she presented to the Emergency Department with confusion and neurological deficits. A computed tomography (CT) scan of the brain revealed a 6.4 cm meningioma in the left frontal lobe. Following a multidisciplinary discussion, the obstetric and neurosurgical teams opted for surgical intervention: a bi-frontal craniotomy with Simpson Grade I resection, performed at 25 weeks' gestation. The post-surgical phase resulted in a positive pregnancy outcome, with the patient delivering a healthy male infant at 38 weeks via planned lower-segment caesarean section. This case highlights the potential for successful obstetric outcomes in pregnant women with brain tumours undergoing second-trimester surgical intervention, potentially negating the need for pregnancy termination.

摘要

本病例报告涉及一例孕期发生的脑肿瘤——具体为脑膜瘤。它描述了一名40岁出头女性的初始诊断、治疗及预后情况。她已育有两胎,妊娠24周+3天时因意识模糊和神经功能缺损就诊于急诊科。脑部计算机断层扫描(CT)显示左额叶有一个6.4厘米的脑膜瘤。经过多学科讨论,产科和神经外科团队选择进行手术干预:在妊娠25周时进行双额开颅手术并进行辛普森一级切除。术后阶段取得了良好的妊娠结局,患者在38周时通过计划中的下段剖宫产分娩出一名健康男婴。本病例凸显了孕中期接受手术干预的脑肿瘤孕妇获得成功产科结局的可能性,这可能使终止妊娠不再必要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/994efc0fa098/cureus-0017-00000086469-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/485cd4d2cc7f/cureus-0017-00000086469-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/693ce19899ef/cureus-0017-00000086469-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/5e7cf86f0664/cureus-0017-00000086469-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/440c45edb876/cureus-0017-00000086469-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/8c2a0b7b4b68/cureus-0017-00000086469-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/994efc0fa098/cureus-0017-00000086469-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/485cd4d2cc7f/cureus-0017-00000086469-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/693ce19899ef/cureus-0017-00000086469-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/5e7cf86f0664/cureus-0017-00000086469-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/440c45edb876/cureus-0017-00000086469-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/8c2a0b7b4b68/cureus-0017-00000086469-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2782/12277926/994efc0fa098/cureus-0017-00000086469-i06.jpg

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本文引用的文献

1
Meningioma during pregnancy: what can influence the management? A case series and review of the literature.妊娠期脑膜瘤:哪些因素会影响治疗决策?病例系列及文献综述
J Matern Fetal Neonatal Med. 2022 Dec;35(25):8767-8777. doi: 10.1080/14767058.2021.2004585. Epub 2021 Nov 25.
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Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions.脑膜瘤:流行病学、病理学、诊断、治疗及未来方向综述
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Epileptic Disord. 2019 Dec 1;21(6):497-517. doi: 10.1684/epd.2019.1105.
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Diagnosis, Treatment, and Management Strategy of Meningioma during Pregnancy.孕期脑膜瘤的诊断、治疗及管理策略
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Epidemiology and etiology of meningioma.脑膜瘤的流行病学和病因学。
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Management of meningiomas.脑膜瘤的管理
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Meningioma surgery in the elderly: a case-control study assessing morbidity and mortality.老年脑膜瘤手术:一项评估发病率和死亡率的病例对照研究
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Hormonal dependency of cerebral meningiomas. Part 2: In vitro effect of steroids, bromocriptine, and epidermal growth factor on growth of meningiomas.脑脑膜瘤的激素依赖性。第2部分:类固醇、溴隐亭和表皮生长因子对脑膜瘤生长的体外作用。
J Neurosurg. 1990 Nov;73(5):750-5. doi: 10.3171/jns.1990.73.5.0750.