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巨大鞍结节脑膜瘤与妊娠相关并发症的同期手术治疗:一例报告及文献综述

Simultaneous surgical management of a giant tuberculum sellae meningioma and pregnancy-related complications: a case report and literature review.

作者信息

Tleubergenov Muratbek A, Ryskeldiyev Nurzhan A, Baymukhanov Dauren S, Zhamoldin Daniyar K, Akshulakov Serik, Doskaliyev Aidos

机构信息

Department of Neurosurgery for Brain Pathology, Joint-Stock Company (JSC) "National Center for Neurosurgery, Astana, Kazakhstan.

Joint-Stock Company (JSC) "National Center for Neurosurgery", Astana, Kazakhstan.

出版信息

Front Oncol. 2025 Jun 4;15:1576797. doi: 10.3389/fonc.2025.1576797. eCollection 2025.

Abstract

Meningiomas, tumors arising from the brain and spinal cord membranes, pose a unique challenge when diagnosed during pregnancy. Their growth can accelerate due to hormonal and hemodynamic changes, necessitating careful clinical evaluation to balance maternal and fetal risks. This article presents a case report and literature review on the successful simultaneous management of a giant tuberculum sellae meningioma and pregnancy-related complications in a 35-year-old woman at 38 weeks of gestation. The patient experienced progressive visual deterioration, prompting an emergency surgical intervention. A multidisciplinary team performed a simultaneous pterional craniotomy with microsurgical tumor resection alongside a cesarean section, ensuring optimal outcomes for both mother and child. Postoperative results demonstrated significant improvement in the patient's vision and neurological function, with a healthy neonate delivered without complications. The histopathological examination confirmed an atypical meningioma (WHO Grade II), reinforcing the need for long-term follow-up and oncological assessment. In addition to the case report, this study reviews the existing literature on meningiomas during pregnancy, focusing on hormonal influences, diagnostic challenges, and treatment strategies. We discuss the role of multimodal imaging, including MRI without contrast, as a primary diagnostic tool and evaluate the risks associated with different treatment approaches. The review highlights the importance of timely surgical intervention, particularly in cases of rapidly growing or symptomatic tumors, and underscores the feasibility of simultaneous neurosurgical and obstetric procedures when clinically indicated. This review emphasizes the necessity of a multidisciplinary approach involving neurosurgeons, obstetricians, anesthesiologists, and neonatologists to optimize both maternal and fetal outcomes. By combining clinical expertise with a thorough literature analysis, we provide valuable insights into the management of intracranial tumors in pregnancy, contributing to the development of treatment protocols for such complex cases.

摘要

脑膜瘤是起源于脑和脊髓膜的肿瘤,在孕期被诊断出来时会带来独特的挑战。由于激素和血流动力学变化,它们的生长可能加速,因此需要仔细的临床评估以平衡母婴风险。本文介绍了一例病例报告并进行文献综述,该病例为一名35岁、孕38周的女性,成功同时处理了巨大鞍结节脑膜瘤及妊娠相关并发症。患者出现进行性视力恶化,促使进行紧急手术干预。一个多学科团队同时进行了翼点开颅显微手术切除肿瘤以及剖宫产手术,确保母婴均获得最佳结果。术后结果显示患者视力和神经功能有显著改善,顺利产下一名健康新生儿,无并发症。组织病理学检查证实为非典型脑膜瘤(世界卫生组织二级),这进一步强调了长期随访和肿瘤学评估的必要性。除了病例报告,本研究还回顾了关于孕期脑膜瘤的现有文献,重点关注激素影响、诊断挑战和治疗策略。我们讨论了多模态成像(包括无对比剂的磁共振成像)作为主要诊断工具的作用,并评估了不同治疗方法相关的风险。该综述强调了及时手术干预的重要性,特别是在肿瘤快速生长或有症状的情况下,并强调了在临床指征明确时同时进行神经外科和产科手术的可行性。本综述强调了多学科方法的必要性,该方法涉及神经外科医生、产科医生、麻醉医生和新生儿科医生,以优化母婴结局。通过将临床专业知识与全面的文献分析相结合,我们为孕期颅内肿瘤的管理提供了有价值的见解,有助于制定此类复杂病例的治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c638/12173878/b1a35ee122ef/fonc-15-1576797-g001.jpg

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