• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

整合单细胞分析揭示卵巢子宫内膜异位症相关性不孕中铁过载诱导的衰老和代谢重编程

Integrative Single-Cell Analysis Reveals Iron Overload-Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis-Associated Infertility.

作者信息

Li Yangshuo, Zhou Wei, Ding Jie, Song Di, Cheng Wen, Yu Jin, Sun Shuai, Mei Shanshan, Liang Xiaolan, Zhao Qianqian, Kuang Yanping, Li Mingqing, Ni Zhexin, Yu Chaoqin, Gao Yue

机构信息

Department of Traditional Chinese Gynecology, the First Affiliated Hospital of Naval Military Medical University, Shanghai, 200433, China.

Beijing Institute of Radiation Medicine, Beijing, 100850, China.

出版信息

Adv Sci (Weinh). 2025 Aug;12(29):e17528. doi: 10.1002/advs.202417528. Epub 2025 Jul 22.

DOI:10.1002/advs.202417528
PMID:40693455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12362736/
Abstract

Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates the effects of iron overload on follicular function in OE-associated infertility (OEI). A single-cell atlas of pre-ovulatory follicular fluid from OEI patients reveals dynamic changes in iron metabolism and iron-induced senescence phenotypes. Spatial transcriptomics using Stereo-seq in iron-overloaded mouse ovaries further identifies localized senescence features. Additional analysis of aging human ovaries highlights conserved patterns of iron dysregulation. These findings provide mechanistic insight into iron overload-related ovarian pathology and suggest potential therapeutic targets for improving oocyte quality in OEI.

摘要

子宫内膜异位症，尤其是卵巢子宫内膜异位症（OE），是不孕症的主要原因，常伴有卵母细胞质量下降和卵巢功能受损。铁过载在OE进展中起关键作用。本研究调查了铁过载对OE相关不孕症（OEI）中卵泡功能的影响。来自OEI患者的排卵前卵泡液单细胞图谱揭示了铁代谢和铁诱导的衰老表型的动态变化。在铁过载小鼠卵巢中使用Stereo-seq进行空间转录组学进一步确定了局部衰老特征。对衰老人类卵巢的额外分析突出了铁失调的保守模式。这些发现为铁过载相关的卵巢病理学提供了机制性见解，并为改善OEI中的卵母细胞质量提出了潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/049bc1257744/ADVS-12-e17528-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/0d0091214bb8/ADVS-12-e17528-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/e91ea706cf1d/ADVS-12-e17528-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/1732fd4a1a30/ADVS-12-e17528-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/4b5ee2814c2e/ADVS-12-e17528-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/2608c66ea422/ADVS-12-e17528-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/3a37d24fe82e/ADVS-12-e17528-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/a7b7257bd043/ADVS-12-e17528-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/049bc1257744/ADVS-12-e17528-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/0d0091214bb8/ADVS-12-e17528-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/e91ea706cf1d/ADVS-12-e17528-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/1732fd4a1a30/ADVS-12-e17528-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/4b5ee2814c2e/ADVS-12-e17528-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/2608c66ea422/ADVS-12-e17528-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/3a37d24fe82e/ADVS-12-e17528-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/a7b7257bd043/ADVS-12-e17528-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa12/12362736/049bc1257744/ADVS-12-e17528-g003.jpg

相似文献

1
Integrative Single-Cell Analysis Reveals Iron Overload-Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis-Associated Infertility.整合单细胞分析揭示卵巢子宫内膜异位症相关性不孕中铁过载诱导的衰老和代谢重编程
Adv Sci (Weinh). 2025 Aug;12(29):e17528. doi: 10.1002/advs.202417528. Epub 2025 Jul 22.
2
[Role of the genetic factors, detoxication systems and oxidative stress in the pathogenesis of endometriosis and infertility (review)].[遗传因素、解毒系统和氧化应激在子宫内膜异位症和不孕症发病机制中的作用（综述）]
Vestn Ross Akad Med Nauk. 2013(8):14-9.
3
N6-methyladenosine methylation regulators can serve as potential biomarkers for endometriosis related infertility.N6-甲基腺苷甲基化调节因子可作为子宫内膜异位症相关性不孕的潜在生物标志物。
Biomol Biomed. 2025 May 8;25(7):1540-1552. doi: 10.17305/bb.2024.11311.
4
Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity.铁过载的卵泡液通过触发颗粒细胞铁死亡和卵母细胞成熟障碍增加子宫内膜异位症相关不孕的风险。
Cell Death Dis. 2022 Jul 4;13(7):579. doi: 10.1038/s41419-022-05037-8.
5
Chronic iron overload disrupts the reproductive tract and leads to infertility: from a clinical case report to the experimental study of reproduction in female mice.慢性铁过载会破坏生殖道并导致不孕：从一例临床病例报告到雌性小鼠生殖的实验研究。
Reprod Toxicol. 2025 Aug 13:109031. doi: 10.1016/j.reprotox.2025.109031.
6
Is the oocyte quality affected by endometriosis? A review of the literature.子宫内膜异位症会影响卵母细胞质量吗？文献综述。
J Ovarian Res. 2017 Jul 12;10(1):43. doi: 10.1186/s13048-017-0341-4.
7
Ovarian endometriosis negatively impacts pregnancy outcomes in young infertile women undergoing IVF/ICSI treatment.卵巢子宫内膜异位症对接受体外受精/卵胞浆内单精子注射治疗的年轻不孕女性的妊娠结局有负面影响。
Eur J Med Res. 2025 Jul 2;30(1):555. doi: 10.1186/s40001-025-02816-9.
8
RNA modifications in female reproductive physiology and disease: emerging roles and clinical implications.RNA修饰在女性生殖生理与疾病中的作用：新出现的作用及临床意义
Hum Reprod Update. 2025 Mar 27. doi: 10.1093/humupd/dmaf005.
9
Reproductive Outcomes in Infertile Women with Endometriosis Undergoing Assisted Reproductive Technology.接受辅助生殖技术的子宫内膜异位症不孕女性的生殖结局
Gynecol Obstet Invest. 2025 Jan 25:1-7. doi: 10.1159/000543213.
10
The Role of miRNA in Endometriosis-Related Infertility-An Update.微小RNA在子宫内膜异位症相关性不孕中的作用——最新进展
Int J Mol Sci. 2025 Jun 19;26(12):5862. doi: 10.3390/ijms26125862.

本文引用的文献

1
Rejuvenation of aged oocyte through exposure to young follicular microenvironment.通过暴露于年轻卵泡微环境来使老化卵母细胞恢复活力。
Nat Aging. 2024 Sep;4(9):1194-1210. doi: 10.1038/s43587-024-00697-x. Epub 2024 Sep 9.
2
Deletion of Fbxw7 in oocytes causes follicle loss and premature ovarian insufficiency in mice.Fbxw7 缺失导致卵母细胞中卵泡耗竭和小鼠卵巢早衰。
J Cell Mol Med. 2024 Jun;28(12):e18487. doi: 10.1111/jcmm.18487.
3
Using clusterProfiler to characterize multiomics data.使用 clusterProfiler 对多组学数据进行特征分析。
Nat Protoc. 2024 Nov;19(11):3292-3320. doi: 10.1038/s41596-024-01020-z. Epub 2024 Jul 17.
4
Iron accumulation in ovarian microenvironment damages the local redox balance and oocyte quality in aging mice.卵巢微环境中铁积累损害衰老小鼠局部氧化还原平衡和卵母细胞质量。
Redox Biol. 2024 Jul;73:103195. doi: 10.1016/j.redox.2024.103195. Epub 2024 May 17.
5
Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1.人类卵巢衰老的时空转录组变化及 FOXP1 的调控作用。
Nat Aging. 2024 Apr;4(4):527-545. doi: 10.1038/s43587-024-00607-1. Epub 2024 Apr 9.
6
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19.铁代谢紊乱和炎症应激性红细胞生成与 COVID-19 的长期结局相关。
Nat Immunol. 2024 Mar;25(3):471-482. doi: 10.1038/s41590-024-01754-8. Epub 2024 Mar 1.
7
Analysis of cell-cell interaction between mural granulosa cells and cumulus granulosa cells during ovulation using single-cell RNA sequencing data of mouse ovary.利用小鼠卵巢单细胞RNA测序数据分析排卵期间壁层颗粒细胞与卵丘颗粒细胞之间的细胞间相互作用。
Reprod Med Biol. 2024 Feb 14;23(1):e12564. doi: 10.1002/rmb2.12564. eCollection 2024 Jan-Dec.
8
Distinct characteristics of the DNA damage response in mammalian oocytes.哺乳动物卵母细胞中 DNA 损伤反应的独特特征。
Exp Mol Med. 2024 Feb;56(2):319-328. doi: 10.1038/s12276-024-01178-2. Epub 2024 Feb 14.
9
The cycling and aging mouse female reproductive tract at single-cell resolution.单细胞分辨率下的周期性和衰老的雌性小鼠生殖道。
Cell. 2024 Feb 15;187(4):981-998.e25. doi: 10.1016/j.cell.2024.01.021. Epub 2024 Feb 6.
10
Impact of endometriosis on the ovarian follicles.子宫内膜异位症对卵巢卵泡的影响。
Best Pract Res Clin Obstet Gynaecol. 2024 Feb;92:102430. doi: 10.1016/j.bpobgyn.2023.102430. Epub 2023 Nov 22.