Renata Hans
Department of Chemistry, Rice University, BioScience Research Collaborative, Houston, TX, 77005, USA.
Chem Soc Rev. 2025 Jul 22. doi: 10.1039/d5cs00453e.
Retrosynthetic strategies are intimately tied to the tools and methods available at the time of their conception. Recent methodological advancements in both radical and biocatalytic reactions have created numerous possibilities for new and unconventional disconnections. Thus, it comes as no surprise that their applications in multi-step syntheses have allowed many complex molecules to be built in ingenious ways. This review summarizes recent case studies wherein radical-based and enzymatic transformations are combined strategically in multi-step sequences to achieve efficient total syntheses of complex natural products.
逆合成策略与构思时可用的工具和方法密切相关。自由基反应和生物催化反应最近在方法学上的进展为新的和非常规的切断反应创造了众多可能性。因此，它们在多步合成中的应用能够以巧妙的方式构建许多复杂分子也就不足为奇了。本综述总结了近期的案例研究，其中自由基反应和酶促转化在多步序列中进行了策略性结合，以实现复杂天然产物的高效全合成。
