Fukai Shohei, Daisaki Hiromitsu, Yoshida Honoka, Shimada Naoki, Motegi Kazuki, Osawa Atsushi, Terauchi Takashi
Department of Nuclear Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
Graduate School of Radiological Technology, Gunma Prefectural College of Health Sciences, 323-1 Kamioki-Machi, Maebashi, Gunma, 371-0052, Japan.
Phys Eng Sci Med. 2025 Jul 22. doi: 10.1007/s13246-025-01608-z.
The Omni Legend (GE Healthcare), equipped with a digital bismuth germanium oxide PET/CT system, has been recently developed. However, the performance of the Omni Legend without a time-of-flight (TOF) system for F-fluciclovine imaging is still unclear. Therefore, this study evaluated the image quality of the Omni Legend according to the Japanese brain tumor phantom test (JBT) criteria, and assessed its potential use for F-fluciclovine imaging. This study followed the JBT procedures. A brain tumor phantom, which includes six hot spheres of different diameters, was filled with an F-fluorodeoxyglucose solution with a radioactivity concentration ratio of 3 (spheres):1 (background). PET scanning was performed using the Omni Legend with a 30-min list mode acquisition. The PET data were reconstructed using an ordered subset expectation maximization (OSEM), an OSEM with point spread function (OSEM + PSF), and a Bayesian penalized likelihood (BPL) under standard clinical parameters. The image quality was evaluated using the JBT criteria, including contrast for a 7.5-mm sphere, recovery coefficient (RC) for a 10.0-mm sphere, standardized uptake value of total background (SUV), and detectability for a 7.5-mm sphere. The contrast, RC, and SUV were 25.1%, 0.70, and 1.00, respectively in OSEM; 25.8%, 0.80, and 0.99 in OSEM + PSF; and 33.8%, 0.93, and 0.99 in BPL. The 7.5-mm sphere was detected by all three methods. All of the JBT criteria were satisfied, regardless of the PET image reconstruction methods. This study demonstrated that the Omni Legend without TOF satisfies all JBT criteria and has the potential to provide high-quality images in F-fluciclovine imaging.
全新开发的Omni Legend（通用电气医疗集团）配备了数字氧化铋锗正电子发射断层扫描/计算机断层扫描（PET/CT）系统。然而，Omni Legend在没有飞行时间（TOF）系统的情况下用于F-氟代脱氧胸苷成像的性能仍不明确。因此，本研究根据日本脑肿瘤体模测试（JBT）标准评估了Omni Legend的图像质量，并评估了其在F-氟代脱氧胸苷成像中的潜在用途。本研究遵循JBT程序。一个包含六个不同直径热球的脑肿瘤体模，填充有放射性浓度比为3（球）:1（背景）的F-氟代脱氧葡萄糖溶液。使用Omni Legend进行PET扫描，采集时间为30分钟列表模式。PET数据在标准临床参数下使用有序子集期望最大化（OSEM）算法、带点扩散函数的OSEM（OSEM + PSF）算法和贝叶斯惩罚似然（BPL）算法进行重建。使用JBT标准评估图像质量，包括7.5毫米球体的对比度、10.0毫米球体的恢复系数（RC）、总背景标准化摄取值（SUV）以及7.5毫米球体的可检测性。在OSEM算法中，对比度、RC和SUV分别为25.1%、0.70和1.00；在OSEM + PSF算法中分别为25.8%、0.80和0.99；在BPL算法中分别为33.8%、0.93和0.99。三种方法均检测到了7.5毫米的球体。无论采用何种PET图像重建方法，所有JBT标准均得到满足。本研究表明，不带TOF的Omni Legend满足所有JBT标准，并且有潜力在F-氟代脱氧胸苷成像中提供高质量图像。
