Farid Mahmoud A, Zeinhom Mohamed G, Ahmed Sherihan Rezk, Ramadan Ehab S
Neuropsychiatry department, Faculty of Medicine, Kafr el-sheikh University, Kafr el- sheikh, Egypt.
Neurol Sci. 2025 Jul 22. doi: 10.1007/s10072-025-08373-7.
White matter hyperintensities (WMHs) increase the burden of migraine on the patients' lives and leading to migraine-related poor outcomes, so we aim to evaluate the association of different neurophysiological, psychological, and clinical factors with the presence and characteristics of WMHs on the brain imaging of migraine patients.
Our study included 300 migraine patients who underwent clinical, psychological, and neurophysiological assessment, including P300, which represented an event-related potential (ERP) component elicited in the decision-making process. The goal was to evaluate the association of these factors with the presence and characteristics of WMHs on the brain imaging of migraine patients.
older age (OR, 1.213; 95% CI, 1.149 to 1.787; P-value 0.02), P300 Fz latency (OR, 1.852; 95% CI, 1.374 to 2.314; P-value < 0.001), P300 Pz latency (OR, 1.823; 95% CI, 1.397 to 4.237; P-value < 0.001), migraine with aura (OR, 7.115; 95% CI, 3.874 to 14.254; P-value 0.01), chronic migraine (OR, 6.105; 95% CI, 3.364 to 8.057; P-value < 0.001), and Montreal cognitive assessment (MoCA) (OR, 0.543; 95% CI, 0.169 to 0.723; P-value < 0.001) were associated with developing WMHs on the brain MRI of migraine patients.
Prolonged P300 latency, older age, lower MoCA score, chronic migraine, and migraine with aura were associated with the presence of WMHs on the brain imaging of migraine patients. In addition, longer P300 latency was positively correlated with WMH diameter, number, and Schelten's score. In contrast, higher P300 amplitude and higher MoCA score were negatively correlated with WMH diameter, number, and Schelten's score in migraine patients.
脑白质高信号（WMHs）增加了偏头痛对患者生活的负担，并导致与偏头痛相关的不良后果，因此我们旨在评估偏头痛患者脑成像中不同神经生理、心理和临床因素与WMHs的存在及特征之间的关联。
我们的研究纳入了300例接受临床、心理和神经生理评估的偏头痛患者，包括P300，它代表决策过程中诱发的一种事件相关电位（ERP）成分。目的是评估这些因素与偏头痛患者脑成像中WMHs的存在及特征之间的关联。
年龄较大（比值比[OR]，1.213；95%置信区间[CI]，1.149至1.787；P值0.02）、P300 Fz潜伏期（OR，1.852；95% CI，1.374至2.314；P值<0.001）、P300 Pz潜伏期（OR，1.823；95% CI，1.397至4.237；P值<0.001）、有先兆偏头痛（OR，7.115；95% CI，3.874至14.254；P值0.01）、慢性偏头痛（OR，6.105；95% CI，3.364至8.057；P值<0.001）和蒙特利尔认知评估（MoCA）（OR，0.543；95% CI，0.169至0.723；P值<0.001）与偏头痛患者脑MRI上出现WMHs有关。
P300潜伏期延长、年龄较大、MoCA评分较低、慢性偏头痛和有先兆偏头痛与偏头痛患者脑成像中WMHs的存在有关。此外，较长的P300潜伏期与WMH直径、数量和斯凯尔特评分呈正相关。相比之下，较高的P300波幅和较高的MoCA评分与偏头痛患者的WMH直径、数量和斯凯尔特评分呈负相关。
