Honda K, Okano Y, Komoda Y, Inoué S
Neurosci Lett. 1985 Nov 20;62(1):137-41. doi: 10.1016/0304-3940(85)90297-6.
An intraperitoneal injection of 0.1 nmol uridine in rats resulted in a transient excess slow-wave sleep if administered shortly before onset of the dark period. The sleep latency was remarkably shortened. A small dose (0.01 nmol) and larger doses (1, 10, 100 nmol) caused no effect. Uridine at a dose of 0.1 nmol was entirely ineffective if injected shortly before onset of the light period, while it resulted in transient excess paradoxical sleep if injected at an early phase of the light period. It is concluded that uridine, if timely administered through a systemic route, may pass the blood-brain barrier to modulate sleep in rats.
给大鼠腹腔注射0.1纳摩尔尿苷，如果在黑暗期开始前不久给药，会导致短暂的慢波睡眠过多。睡眠潜伏期显著缩短。小剂量（0.01纳摩尔）和大剂量（1、10、100纳摩尔）均无效果。如果在光照期开始前不久注射，0.1纳摩尔剂量的尿苷完全无效，而在光照期早期注射则会导致短暂的快速眼动睡眠过多。结论是，尿苷如果通过全身途径及时给药，可能会穿过血脑屏障来调节大鼠的睡眠。
