Hussain Md Sadique, Khan Yumna, Maqbool Mudasir, Khan Gyas, Mawkili Wedad, Kamli Faroq, Hanbashi Ali, Alam Prawez
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
Institute of Biotechnology and Genetic Engineering (Health Division), The University of Agriculture, Peshawar, Pakistan.
Epigenomics. 2025 Jul 22:1-25. doi: 10.1080/17501911.2025.2535938.
Prostate cancer (PCa) is one of the most common cancers in men, distinguished by a multifaceted pathogenesis that involves substantial epigenetic modifications. This article emphasizes the critical role of chromatin remodeling in PCa advancement. Chromatin remodeling, a key epigenetic mechanism, influences gene expression by modulating the chromatin structure through the action of specialized complexes such as SWI/SNF, ISWI, CHD, & INO80, thereby regulating genes vital to tumor progression. A comprehensive literature search was conducted using PubMed, Web of Science, and Scopus databases for studies published between 2000 and 2025, focusing on chromatin remodeling, epigenetic alterations, and therapeutic strategies in PCa. The review discusses the major epigenetic changes observed in PCa, including DNA and RNA methylation, histone modifications, and non-coding RNA (ncRNA)-mediated chromatin remodeling. The evolving epigenetic landscape shaped by these alterations offers insights into novel therapeutic opportunities. The clinical relevance of targeting chromatin remodeling complexes is explored, alongside existing therapies and potential future interventions. This review also addresses challenges in studying chromatin remodeling and highlights emerging technologies that could enhance understanding of PCa epigenetics. This comprehensive exploration underscores the promise of chromatin remodeling as both a biomarker and a therapeutic target in PCa management.
前列腺癌（PCa）是男性最常见的癌症之一，其发病机制具有多方面特点，涉及大量表观遗传修饰。本文强调染色质重塑在前列腺癌进展中的关键作用。染色质重塑是一种关键的表观遗传机制，通过诸如SWI/SNF、ISWI、CHD和INO80等特殊复合物的作用来调节染色质结构，从而影响基因表达，进而调控对肿瘤进展至关重要的基因。我们使用PubMed、科学网和Scopus数据库对2000年至2025年发表的研究进行了全面的文献检索，重点关注前列腺癌中的染色质重塑、表观遗传改变和治疗策略。该综述讨论了在前列腺癌中观察到的主要表观遗传变化，包括DNA和RNA甲基化、组蛋白修饰以及非编码RNA（ncRNA）介导的染色质重塑。这些改变所形成的不断演变的表观遗传格局为新的治疗机会提供了见解。我们探讨了靶向染色质重塑复合物的临床相关性，以及现有的治疗方法和潜在的未来干预措施。本综述还讨论了研究染色质重塑所面临的挑战，并强调了能够增进对前列腺癌表观遗传学理解的新兴技术。这一全面的探索强调了染色质重塑作为前列腺癌管理中的生物标志物和治疗靶点的前景。
