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老年干预措施对因胃癌接受择期胃切除术的体弱老年患者术后结局的影响。

Effect of geriatric interventions on postoperative outcomes in frail older patients undergoing elective gastrectomy for gastric cancer.

作者信息

Chang Chieh-Ying, Lu Chang-Hsien, Hung Chia-Yen, Liu Keng-Hao, Hsu Jun-Te, Tsai Chun-Yi, Yeh Ta-Sen, Hung Yu-Shin, Chou Wen-Chi

机构信息

Department of Hematology and Oncology, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Department of Hematology and Oncology, Chang Gung Memorial Hospital at Chiayi, Chiayi, Taiwan.

出版信息

J Geriatr Oncol. 2025 Sep;16(7):102324. doi: 10.1016/j.jgo.2025.102324. Epub 2025 Jul 21.

Abstract

INTRODUCTION

Postoperative complications are common after gastrectomy for gastric cancer, particularly in older patients with increased frailty. This study evaluates the impact of targeted geriatric interventions on postoperative outcomes in frail older patients undergoing gastrectomy.

MATERIALS AND METHODS

A total of 120 frail patients aged 65 years and older were enrolled in a before-and-after study design. Participants were divided into a standard care group (n = 52) and an intervention group (n = 68) of comparable characteristics. All participants underwent a comprehensive geriatric assessment (CGA) before surgery to identify frailty. The intervention group received targeted geriatric interventions consisting of nutritional support, comorbidity management, and physical therapy in addition to standard care. Postoperative outcomes, including length of hospital stay (LOS), intensive care unit (ICU) admission rates, and postoperative complications were compared between the groups.

RESULTS

The intervention group demonstrated significantly lower rates of ICU admissions (11.8% vs. 34.6%, p = 0.003), emergency room visits (2.1% vs. 42.3%, p = 0.02), and 30-day readmissions (14.7% vs. 32.7%, p = 0.02) compared to the standard care group. The median LOS was comparable between the groups (18 days vs. 19 days, p = 0.73). While overall complication rates (10.3% vs. 21.2%, p = 0.10) and 30-, 90-, and 180-day postoperative mortality rates were numerically lower in the intervention group, these differences were not statistically significant.

DISCUSSION

Targeted geriatric interventions during the perioperative period significantly reduced ICU admissions, emergency room visits, and hospital readmissions among frail older patients undergoing gastrectomy for gastric cancer. These findings support the routine integration of geriatric care strategies to improve postoperative recovery and reduce adverse outcomes in older surgical patients.

摘要

引言

胃癌胃切除术后并发症很常见,尤其是在身体更虚弱的老年患者中。本研究评估了针对性老年干预措施对接受胃切除术的虚弱老年患者术后结局的影响。

材料与方法

共有120名65岁及以上的虚弱患者参与了一项前后对照研究设计。参与者被分为特征相似的标准治疗组(n = 52)和干预组(n = 68)。所有参与者在手术前均接受了全面的老年评估(CGA)以确定虚弱程度。干预组除接受标准治疗外,还接受了包括营养支持、合并症管理和物理治疗在内的针对性老年干预措施。比较两组的术后结局,包括住院时间(LOS)、重症监护病房(ICU)入住率和术后并发症。

结果

与标准治疗组相比,干预组的ICU入住率(11.8%对34.6%,p = 0.003)、急诊就诊率(2.1%对42.3%,p = 0.02)和30天再入院率(14.7%对32.7%,p = 0.02)显著更低。两组的中位住院时间相当(18天对19天,p = 0.73)。虽然干预组的总体并发症发生率(10.3%对21.2%,p = 0.10)以及术后30天、90天和180天的死亡率在数值上更低,但这些差异无统计学意义。

讨论

围手术期针对性的老年干预措施显著降低了接受胃癌胃切除术的虚弱老年患者的ICU入住率、急诊就诊率和医院再入院率。这些发现支持将老年护理策略常规纳入,以改善老年手术患者的术后恢复并减少不良结局。

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