Wei Xin-Yue, Gong Xiao-Juan, Ji Hong
Department of Pediatrics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2025 Jul 15;27(7):881-887. doi: 10.7499/j.issn.1008-8830.2412098.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING) signaling pathway is a crucial component of the immune system. It detects abnormal cytosolic double-stranded DNA and promotes the expression of type I interferons and other inflammatory factors, thereby protecting the body from pathogenic infections. In children, an immature immune system or genetic mutations can lead to immune dysregulation, increasing the risk of autoimmune diseases (AID) and autoinflammatory diseases. Recent studies have shown that aberrant activation of the cGAS-STING signaling pathway is associated with the development of AID and autoinflammatory diseases in children. This review summarizes the research progress on the cGAS-STING signaling pathway in childhood AID and autoinflammatory diseases, aiming to provide new directions for clinical diagnosis and treatment.
环磷酸鸟苷-腺苷酸合成酶（cGAS）-干扰素基因刺激因子（STING）信号通路是免疫系统的关键组成部分。它能检测到异常的胞质双链DNA，并促进I型干扰素和其他炎症因子的表达，从而保护身体免受病原体感染。在儿童中，免疫系统不成熟或基因突变可导致免疫失调，增加自身免疫性疾病（AID）和自身炎症性疾病的风险。最近的研究表明，cGAS-STING信号通路的异常激活与儿童AID和自身炎症性疾病的发生有关。本文综述了儿童AID和自身炎症性疾病中cGAS-STING信号通路的研究进展，旨在为临床诊断和治疗提供新的方向。
