Jiang Jiamiao, Liang Haiying, Ye Yicheng, Huang Weichang, Miao Jiajun, Tan Haixin, Hu Ziwei, Tian Hao, Qin Hanfeng, Zhang Xiaoting, Zhang Lishan, Gao Junbin, Shen Xian, Wang Shuanghu, Peng Fei, Tu Yingfeng
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Nat Commun. 2025 Jul 22;16(1):6754. doi: 10.1038/s41467-025-61914-8.
Healing complex wounds, especially deep injuries, requires therapies that can target different healing phases while penetrating physical barriers like fibrin clots and scab. Existing approaches fail to fully address these spatiotemporal challenges due to reliance on passive drug diffusion. Here, we develop magnetic microspheres loaded with therapeutic factors derived from stem cells (collectively called the "secretome") to actively guide wound repair. These microspheres provide sustained release of bioactive factors and can be precisely navigated using external magnetic fields. In vitro, they exhibit potent anti-inflammatory effects and progressively enhance skin cell proliferation and migration. Unlike conventional therapies, magnetic propulsion allows them to penetrate dense wound barriers more effectively. In male murine full-thickness wounds, the micromotors accelerate healing by promoting tissue regeneration, reducing inflammation, and improving collagen and blood vessel formation. Successful results in male pigs further confirm their cross-species potential. By combining magnetic mobility with a composite bioactive secretome, this platform overcomes both spatial and temporal limitations in wound treatment.
愈合复杂伤口，尤其是深度损伤，需要能够针对不同愈合阶段同时穿透诸如纤维蛋白凝块和痂皮等物理屏障的治疗方法。由于依赖被动药物扩散，现有方法无法完全应对这些时空挑战。在此，我们开发了负载源自干细胞的治疗因子（统称为“分泌组”）的磁性微球，以积极引导伤口修复。这些微球可实现生物活性因子的持续释放，并可利用外部磁场进行精确导航。在体外，它们表现出强大的抗炎作用，并逐步增强皮肤细胞的增殖和迁移。与传统疗法不同，磁性推进使它们能够更有效地穿透致密的伤口屏障。在雄性小鼠全层伤口中，这些微型马达通过促进组织再生、减轻炎症以及改善胶原蛋白和血管形成来加速愈合。在雄性猪身上取得的成功结果进一步证实了它们的跨物种潜力。通过将磁驱动与复合生物活性分泌组相结合，该平台克服了伤口治疗中的空间和时间限制。
