Routinely collected blood tests can reflect underlying pathophysiological processes. We demonstrate that the dynamics of routinely collected blood tests hold prediction validity in acute Spinal Cord Injury (SCI). Using MIMIC data (n = 2615) for modeling and TRACK-SCI study data (n = 137) for validation, we identified multiple trajectories for common blood markers. We developed machine learning models for the dynamic prediction of in-hospital mortality, SCI occurrence in spine trauma patients, and SCI severity (motor complete vs. incomplete). The in-hospital mortality model achieved an out-of-train ROC-AUC of 0.79 [0.77-0.81] day one post-injury, improving to 0.89 [0.88-0.89] by day 21. For detecting the presence of SCI after spine trauma, the highest ROC-AUC was 0.71 [0.69-0.72] achieved by day 21. By day seven, the ROC-AUC for SCI severity was 0.81 [0.77-0.85]. Our full models outperformed the severity score SAPS II following seven days of hospitalization.