Gad Ashraf, Mesilhy Rowan, Maveli Thomas, Ali Fatima, Jasim Noora, Adam Malaz, Abdalla Tasneim, Madani Mohamed, Alkhateeb Mohammad Ayman, Bayoumi Mohammad A A
Neonatal Intensive Care Unit, Women's Wellness and Research Centre, Hamad Medical Corporation, P.O. Box: 3050, Doha, Qatar.
Faculty of Medicine, Qatar University, Doha, Qatar.
Sci Rep. 2025 Jul 22;15(1):26651. doi: 10.1038/s41598-025-12066-8.
To investigate the respiratory and related health outcomes at 18 months for extremely preterm (EP) infants diagnosed with bronchopulmonary dysplasia (BPD). This retrospective cohort study aims to investigate the respiratory and related health outcomes at 18 months for extremely preterm (EP) infants diagnosed with bronchopulmonary dysplasia (BPD). Also, rephrase the second sentence to be: We reviewed post-hospital discharge outcomes for EP infants with BPD from Women's Health and Research Centre, Doha, Qatar (January 2018 - December 2019). We compared 86 BPD infants with 102 preterm controls without BPD. EP infants with BPD were more often male (70% vs. 46%, p < 0.001), had lower birth weights (797 g vs. 920 g) and gestational ages (25.3 vs. 25.9 weeks, both p < 0.001). They required more surfactant, longer ventilation, and experienced higher rates of complications. Post-discharge, infants with BPD had significantly higher rates of oxygen dependence, steroid use (both systemic and inhaled), gastric tube feeding, and sleep study evaluations compared to those without BPD. Regression analysis revealed that moderate and severe BPD were significantly associated with increased risk of pediatric intensive care unit admissions, pulmonary hypertension, any patent ductus arteriosus closure procedure, and neurodevelopmental impairment. Specifically, severe BPD was strongly associated with home gastric tube feeding (OR 67.3; 95% CI: 6.48-699.67; p < 0.001), motor delays (OR 6.29; 95% CI: 1.61-24.54; p < 0.001), and expressive language delays (OR 4.39; 95% CI: 1.15-16.77; p = 0.031). BPD infants have significantly poorer respiratory and neurodevelopmental outcomes, highlighting the need for intensive monitoring and follow-up care. While this retrospective study provides valuable insights, further prospective research is warranted to validate these findings and explore targeted interventions.
研究诊断为支气管肺发育不良（BPD）的极早产儿（EP）在18个月时的呼吸及相关健康结局。本回顾性队列研究旨在调查诊断为支气管肺发育不良（BPD）的极早产儿（EP）在18个月时的呼吸及相关健康结局。此外，将第二句话改写为：我们回顾了卡塔尔多哈妇女健康与研究中心（2018年1月 - 2019年12月）患有BPD的极早产儿出院后的结局。我们将86名BPD婴儿与102名无BPD的早产对照婴儿进行了比较。患有BPD的极早产儿男性比例更高（70%对46%，p < 0.001），出生体重更低（797克对920克），胎龄更小（25.3周对25.9周，p均< 0.001）。他们需要更多的表面活性剂、更长时间的通气，且并发症发生率更高。出院后，与无BPD的婴儿相比，患有BPD的婴儿氧依赖、使用类固醇（全身和吸入）、胃管喂养以及睡眠研究评估的发生率显著更高。回归分析显示，中度和重度BPD与儿科重症监护病房入院、肺动脉高压、任何动脉导管未闭闭合手术以及神经发育障碍风险增加显著相关。具体而言，重度BPD与家庭胃管喂养（OR 67.3；95% CI：6.48 - 699.67；p < 0.001）、运动发育迟缓（OR 6.29；95% CI：1.61 - 24.54；p < 0.001）以及表达性语言发育迟缓（OR 4.39；95% CI：1.15 - 16.77；p = 0.031）密切相关。患有BPD的婴儿呼吸和神经发育结局明显更差，凸显了强化监测和后续护理的必要性。虽然这项回顾性研究提供了有价值的见解，但仍需要进一步的前瞻性研究来验证这些发现并探索有针对性的干预措施。
