Robin J B, Jester J V, Nobe J, Nicolaides N, Smith R E
Ophthalmology. 1985 Oct;92(10):1423-6. doi: 10.1016/s0161-6420(85)33848-4.
Meibomian gland transillumination biomicroscopy and infrared photography were performed on 18 patients with clinically evident meibomian gland dysfunction (MGD) and dermatologic rosacea, 22 patients having MGD without evidence of dermatologic rosacea, and 15 unaffected individuals who served as controls. All patients having clinical signs of MGD demonstrated morphologic abnormalities of their meibomian glands by transilluminated biomicroscopy. Patients without dermatologic rosacea were noted to have varying degrees of gland distortion. Moreover, infrared photography documented a loss of the normal grape-like clusters of dark spots that represent the gland, suggesting a loss of glandular acini. Patients with dermatologic rosacea had more severe alterations, including marked distortion and loss of normal gland anatomy. There were no such abnormalities in clinically unaffected individuals. These data demonstrate that transilluminated biomicroscopy and infrared photography have the ability to identify a spectrum of morphologic alterations of the meibomian glands in MGD patients. The authors suggest that these techniques could be used to classify clinical MGD based upon the presence or absence of identifiable meibomian gland abnormalities.
对18例有临床明显睑板腺功能障碍（MGD）且患有皮肤酒渣鼻的患者、22例有MGD但无皮肤酒渣鼻证据的患者以及15名作为对照的未受影响个体进行了睑板腺透照生物显微镜检查和红外摄影。所有有MGD临床体征的患者通过透照生物显微镜检查均显示睑板腺形态异常。无皮肤酒渣鼻的患者存在不同程度的腺体扭曲。此外，红外摄影记录到代表腺体的正常葡萄状黑点簇消失，提示腺泡丢失。患有皮肤酒渣鼻的患者有更严重的改变，包括明显的扭曲和正常腺体解剖结构的丧失。临床未受影响的个体没有此类异常。这些数据表明，透照生物显微镜检查和红外摄影能够识别MGD患者睑板腺的一系列形态学改变。作者建议，这些技术可用于根据是否存在可识别的睑板腺异常对临床MGD进行分类。
