Pan Huiwen, Wang Xiangyang, Zheng Lijie, Wang Jinye, Ding Guowen, Zhu Jingfeng, Fang Zhijie
The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Troop 73071 of the PLA, Xuzhou, Jiangsu, China.
Clin Respir J. 2025 Jul;19(7):e70113. doi: 10.1111/crj.70113.
The objective of this study is to investigate the genetic susceptibility and risk factors of EGF gene rs1897990 and rs1524106 in lung adenocarcinoma young patients aged ≤ 45 years.
A case-control study was conducted. DNA was extracted and identified from 88 samples from case and control groups by single-nucleotide polymorphism assay. PCR amplification was performed by TaqMan probe method, and the factors of smoking, drinking, sex, and age were also included. To investigate the clinical factors and genotyping differences between case and control groups.
Smoking was an influential factor in young lung adenocarcinoma patients. The mutation frequency of EGF gene rs1897990 CT heterozygous mutant was different between the two groups (p = 0.021). The T alleles of EGF rs1897990 and rs1524106 were significantly different between the two groups (p = 0.034 and p = 0.023).
The young lung adenocarcinoma population (≤ 45 years old) is susceptible to EGF rs1897990 and rs1524106 variants, with smoking being another risk factor. Additionally, smoking may enhance the risk of EGF rs1897990 and rs1524106 variants threatening the development of lung adenocarcinoma.
本研究旨在调查年龄≤45岁的肺腺癌年轻患者中表皮生长因子（EGF）基因rs1897990和rs1524106的遗传易感性及危险因素。
进行病例对照研究。通过单核苷酸多态性分析从病例组和对照组的88份样本中提取并鉴定DNA。采用TaqMan探针法进行聚合酶链反应（PCR）扩增，同时纳入吸烟、饮酒、性别和年龄等因素。以研究病例组和对照组之间的临床因素及基因分型差异。
吸烟是年轻肺腺癌患者的一个影响因素。两组之间EGF基因rs1897990的CT杂合突变频率存在差异（p = 0.021）。EGF rs1897990和rs1524106的T等位基因在两组之间有显著差异（p = 0.034和p = 0.023）。
年龄≤45岁的年轻肺腺癌人群易患EGF rs1897990和rs1524106变异，吸烟是另一个危险因素。此外，吸烟可能会增加EGF rs1897990和rs1524106变异威胁肺腺癌发展的风险。
