丹酚酸A抑制急性冠脉综合征患者血小板的活化和聚集。
Salvianolic acid A inhibits the activation and aggregation of platelets in patients with acute coronary syndrome.
作者信息
Wang Peipei, Zhang Shunqiong, Li Xinyuan, Xie Shuanglin, Mei Yibin, Zhang Wei, Mamun Abdullah A I, Lu Wenjuan, Liang Taoqing, Zeng Chunlai
机构信息
Department of Cardiology, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
出版信息
Medicine (Baltimore). 2025 Jul 18;104(29):e43305. doi: 10.1097/MD.0000000000043305.
BACKGROUND
The acute blockage in coronary arteries further causes acute coronary syndrome (ACS). There are 2 main factors implicated in the activation and aggregation of platelets. However, this present study aimed to investigate the effect of salvianolic acid A (SAA) on the platelets in patients with ACS and explore its potential mechanism of action.
METHODS
The impact of SAA on platelets under different stimulation conditions was studied using flow cytometry and platelet aggregation detection techniques.
RESULTS
The results demonstrated that in 40 ACS patients, ex vivo treatment of platelets with SAA (0.1 mg/ml) significantly reduced aggregation and activation. Intriguingly, we found no significant difference between the 3 types of ACS patients in the antiplatelet effect of SAA. Moreover, the results indicated that C-reactive protein, alanine aminotransferase, C-reactive protein-to-albumin ratio, total cholesterol, and low-density lipoprotein levels were negatively correlated with the anti-platelet effect of SAA in ACS patients and that a history of smoking may reduce the anti-platelet effect of SAA in the same group.
CONCLUSION
In summary, the above findings of this study highlight the therapeutic potential of SAA against platelets in patients with ACS, providing new insights into clinical treatment and experimental research.
背景
冠状动脉急性阻塞会进一步引发急性冠状动脉综合征（ACS）。血小板的激活和聚集涉及两个主要因素。然而，本研究旨在探讨丹酚酸A（SAA）对ACS患者血小板的影响，并探究其潜在作用机制。
方法
采用流式细胞术和血小板聚集检测技术研究SAA在不同刺激条件下对血小板的影响。
结果
结果表明，在40例ACS患者中，用SAA（0.1mg/ml）对血小板进行体外处理可显著降低聚集和激活。有趣的是，我们发现3种类型的ACS患者在SAA的抗血小板作用方面无显著差异。此外，结果表明，C反应蛋白、丙氨酸转氨酶、C反应蛋白与白蛋白比值、总胆固醇和低密度脂蛋白水平与ACS患者中SAA的抗血小板作用呈负相关，且吸烟史可能会降低同一组中SAA的抗血小板作用。
结论
综上所述，本研究的上述发现突出了SAA对ACS患者血小板的治疗潜力，为临床治疗和实验研究提供了新的见解。
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